Rectal Toxicity After Extremely Hypofractionated Radiotherapy Using a Non-Isocentric Robotic Radiosurgery System for Early Stage Prostate Cancer
Bibliographic record
Abstract
Background: The aim of the study was to evaluate toxicity after extremely hypofractionated radiotherapy (EHF-RT) using a non-isocentric robotic radiosurgery system for early stage prostate cancer. Methods: Eligibility criteria of this feasibility study were 50 - 84 years old, and low-risk to intermediate-risk disease. The prescribed dose to the iso-dose line of 95% of planning target volume was 35 Gy in five fractions over 2 weeks. The primary endpoint was the incidence of >= grade 2 acute toxicity which indicated symptoms requiring medications. Results: We enrolled 20 patients from December 2012 to August 2014, and the median follow-up time was 30 months (range: 18 - 36). Sixteen patients had a short overall treatment time (OTT) of EHF-RT (9 - 10 days), and four patients had a long OTT (11 - 12 days) because of national holidays and patient's preference. The incidences of >= grade 2 acute toxicity in all sites, that in the rectum, and that in the genitourinary system, were 30%, 20%, and 10%, respectively. No patient developed severe acute toxicity (>=grade 3). Among 16 patients with a short OTT of EHF-RT, four patients developed grade 2 acute rectal toxicity. Rectum-V 28 Gy (rectal volume receiving >= 28 Gy) of 3.8 mL or higher had a tendency to increase grade 2 acute rectal toxicity (P = 0.058). One patient developed grade 3 late rectal toxicity and no patient developed severe late genitourinary toxicity. Conclusion: The incidences of >= grade 2 acute toxicity in all sites and that in the rectum after EHF-RT of 35 Gy in five fractions were 30% and 20%, respectively. High rectum-V 28 Gy was associated with grade 2 acute rectal toxicity after EHF-RT for early prostate cancer. World J Oncol. 2016;7(5-6):98-103 doi: https://doi.org/10.14740/wjon986w
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".