Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for <i>CYP2C19</i> and Voriconazole Therapy
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
Machine scores (provisional)
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
- Teacher spread
- 0.216 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
Voriconazole, a triazole antifungal agent, demonstrates wide interpatient variability in serum concentrations, due in part to variant CYP2C19 alleles. Individuals who are CYP2C19 ultrarapid metabolizers have decreased trough voriconazole concentrations, delaying achievement of target blood concentrations; whereas poor metabolizers have increased trough concentrations and are at increased risk of adverse drug events. We summarize evidence from the literature supporting this association and provide therapeutic recommendations for the use of voriconazole for treatment based on CYP2C19 genotype (updates at https://cpicpgx.org/guidelines/ and www.pharmgkb.org).
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- Clinical Pharmacology & Therapeutics
- Topic
- Antifungal resistance and susceptibility
- Field
- Medicine
- Canadian institutions
- —
- Funders
- National Institute of General Medical SciencesNational Human Genome Research InstituteNational Cancer InstituteChildren's Mercy HospitalNational Institutes of HealthSick Kids FoundationInstituto de Salud Carlos IIIFederación Española de Enfermedades Raras
- Keywords
- CYP2C19PharmacogeneticsVoriconazoleMedicineMedical physicsInternal medicineBiologyGenotype
- Has abstract in OpenAlex
- yes