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Record W2563348153 · doi:10.1055/s-0036-1596222

Validation of chemometric methods for plant authentication

2016· article· en· W2563348153 on OpenAlexaff
PN Brown

Bibliographic record

VenuePlanta Medica · 2016
Typearticle
Languageen
FieldChemistry
TopicSpectroscopy and Chemometric Analyses
Canadian institutionsBritish Columbia Institute of Technology
Fundersnot available
KeywordsGinsengIngredientTraditional medicineFolk medicineActive ingredientBiologyBotanyFood scienceBiotechnologyChemistryMedicinePharmacology

Abstract

fetched live from OpenAlex

The authenticity of botanical ingredients in marketed products has been the focus of widespread concern in the natural product and dietary supplement industry. Classically, plants are identified by physical examination of minimally processed biomass for diagnostic macroscopic and microscopic features. However, botanical ingredients in modern ingredient supply chains are harvested when floral parts are absent, utilize parts of the plant that lack flowers (e.g., roots) or are so highly processed that diagnostic anatomical features have been destroyed or removed (e.g., extracts). Chemical profiling of extracts with chemometric analyses shows promise as an approach for authenticating botanicals. Adulteration of ginseng ( Panax spp.) roots with Panax leaves is a common and attractive adulteration as leaves are considered useless by-products of ginseng cultivation despite having higher ginsenoside content than roots, thereby giving the false appearance of higher quality and potency. Chemical profiling by HPLC-UV shows unique chemical profiles for leaf versus root materials and using SIMCA it is possible to differentiate root from leaf and to detect high levels of adulteration. However using a new multivariate moving window PCA approach has allowed us to detect much lower levels of adulteration in products based on the PC score residuals of unknown samples. This represents a significant improvement over past statistical techniques that resulted in significantly improved detection limits compared with traditional regression models for detection of low level of contamination [1]. Acknowledgements: Funding provided by Canada Research Chairs.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.013
metaresearch head score (Gemma)0.032
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Methods · Consensus signal: Methods
Teacher disagreement score0.013
Threshold uncertainty score0.068

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0130.032
Meta-epidemiology (narrow)0.0020.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0050.004
Science and technology studies0.0010.001
Scholarly communication0.0020.002
Open science0.0010.002
Research integrity0.0020.002
Insufficient payload (model declined to judge)0.0020.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.033
GPT teacher head0.356
Teacher spread0.323 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2016
Admission routes1
Has abstractyes

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