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A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer’s Disease

2016· article· en· 536 citations· W2563754444 on OpenAlex· 10.1016/j.cels.2016.11.006

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian funderA Canadian agency funded it. The work may carry no Canadian affiliation at all.

No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.014
GPT teacher head0.224
Teacher spread
0.209 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

No abstract. This is not a gap in this database — OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

The record

Venue
Cell Systems
Topic
Bioinformatics and Genomic Networks
Field
Biochemistry, Genetics and Molecular Biology
Canadian institutions
Funders
Alzheimer’s Research UKUniversity of British ColumbiaWeston Brain InstituteNational Institute of Neurological Disorders and StrokeAlzheimer's AssociationNational Institute on AgingAlzheimer's Disease Research Center, Emory UniversityEmory UniversityMichael J. Fox Foundation for Parkinson's ResearchU.S. Department of Veterans Affairs
Keywords
DiseaseAsymptomaticExpression (computer science)Alzheimer's diseaseComputational biologyBiologyNeuroscienceMedicineGeneticsComputer scienceInternal medicine
Has abstract in OpenAlex
no