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Record W2565865237

Automation of a Multiplexed Microbead-based DNA Assay Platform

2015· dissertation· en· W2565865237 on OpenAlexaboutno aff
Albert Lam

Bibliographic record

VenueTSpace (University of Toronto) · 2015
Typedissertation
Languageen
FieldEngineering
TopicBiosensors and Analytical Detection
Canadian institutionsnot available
Fundersnot available
KeywordsMicrobead (research)AutomationLeverage (statistics)Point of careEngineeringMultiplexingMicrofluidicsComputer scienceNanotechnologyTelecommunicationsArtificial intelligenceMedicineBiology
DOInot available

Abstract

fetched live from OpenAlex

Microbead-based diagnostic technology has been explored in academia for over 30 years. As the technology matured, it became clear that this was a competitive platform for multiplexed point- of-care diagnostics for a number of different applications spanning from healthcare, border defense, food safety and environmental monitoring. To realize the benefits of this technology to Canada and the rest of the world, it is imperative to develop an automation scheme to enable minimally trained users to be able to leverage this technology in a point-of-care setting where there is no access to a full lab, and often without reliable water or electricity. This thesis aims to leverage the use of microfluidics and magnetism to enable a simple way of automating the microbead platform for this purpose.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.735
Threshold uncertainty score0.999

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.012
GPT teacher head0.221
Teacher spread0.209 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2015
Admission routes1
Has abstractyes

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