Rh glycoprotein immunoreactivity in the skin and its role in extrabranchial ammonia excretion by the sea lamprey (<i>Petromyzon</i><i> marinus</i>) in fresh water
Bibliographic record
Abstract
Aquatic organisms employ various strategies to excrete ammonia across the gills, skin, and (or) renal routes. During three different stages of their life cycle, we hypothesized that the basal vertebrate sea lamprey (Petromyzon marinus L., 1758) used the skin as a route for ammonia excretion. Measurements of ammonia excretion using divided flux chambers revealed that extrabranchial sites (skin plus renal) of ammonia excretion were quantitatively more important in larval sea lampreys, but following metamorphosis, the gills became the dominant route of excretion in juvenile sea lampreys. Despite the greater relative importance of the skin in the larval stage, Rh glycoprotein isoforms Rhbg, Rhcg1, and Rhcg2 were detected in the skin in all three sea lamprey life stages examined, but the patterns of expression were dependent on the life stage. We conclude that, during the relatively sedentary filter-feeding larval stage, extrabranchial routes play an equally important role as the gill in facilitating ammonia excretion. However, the gills by virtue of their extensive branchial vasculature become the dominant route of ammonia excretion following metamorphosis because of the need to offload greater amounts of ammonia arising from higher rates of basal ammonia production and the potential to excrete higher amounts of ammonia following ingestion of protein-rich blood in the parasitic stage.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".