Genome-wide Association Study of Fat intake in Adolescence
Bibliographic record
Abstract
Dietary preference for fat, which increases risk for obesity, is a complex behavior regulated in part by the brain-reward system. We conducted a genome-wide association study (GWAS) to search for loci associated with relative fat intake in 598 adolescents (12-18 years) who were recruited from the French-Canadian founder population. The GWAS identified a locus in the μ-opioid receptor gene (OPRM1, rs2281617, p=5.2x10-6), which encodes a receptor expressed in the brain-reward system and which has been shown previously to modulate fat preference in animals. The minor OPRM1 allele appeared to have a “protective” effect: it was associated with lower fat intake and lower body-fat mass, In addition, OPRM1 was associated with relative fat intake in an independent sample of 490 young adults. In summary, OPRM1 may modulate dietary preference for fat and hence the risk for obesity. Further studies are required to confirm our findings.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".