A role for the histone H2A deubiquitinase <scp>MYSM</scp>1 in maintenance of <scp>CD</scp>8<sup>+</sup> T cells
Why this work is in the frame
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Bibliographic record
Abstract
Summary Several previous studies outlined the importance of the histone H2A deubiquitinase MYSM 1 in the regulation of stem cell quiescence and haematopoiesis. In this study we investigated the role of MYSM 1 in T‐cell development. Using mouse models that allow conditional Mysm1 ablation at late stages of thymic development, we found that MYSM 1 is intricately involved in the maintenance, activation and survival of CD 8 + T cells. Mysm1 ablation resulted in a twofold reduction in CD 8 + T‐cell numbers, and also led to a hyperactivated CD 8 + T‐cell state accompanied by impaired proliferation and increased pro‐inflammatory cytokine production after ex vivo stimulation. These phenotypes coincided with an increased apoptosis and preferential up‐regulation of p53 tumour suppressor protein in CD 8 + T cells. Lastly, we examined a model of experimental cerebral malaria, in which pathology is critically dependent on CD 8 + T cells. In the mice conditionally deleted for Mysm1 in the T‐cell compartment, CD 8 + T‐cell numbers remained reduced following infection, both in the periphery and in the brain, and the mice displayed improved survival after parasite challenge. Collectively, our data identify MYSM 1 as a novel factor for CD 8 + T cells in the immune system, increasing our understanding of the role of histone H2A deubiquitinases in cytotoxic T‐cell biology.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it