Prostate Cancer as a Metabolic Disease - Is Prostate Cancer Diagnosis Associated with Worse Cardiovascular Outcomes?
Bibliographic record
Abstract
Metabolic syndrome (MetS) and prostate cancer (PC) share several risk factors. In addition to increased cardiovascular risk, there is evidence that men with MetS have an increased PC risk. Given that both diseases develop over decades, PC diagnosis may precede the onset of MetS, and may be an early indicator of cardiovascular risk. We sought to determine if PC diagnosis is associated with increased risk of subsequent cardiovascular event. In our population-based study using administrative databases, men with PC identified using the Ontario Cancer Registry were hard-matched and propensity score-matched to men without PC diagnosis identified using the Registered Persons Database. Competing risks analyses were performed to compare risk of cardiovascular events. Contrary to our hypothesis, men with PC were less likely to experience a cardiovascular event compared to men without PC (sub-distributional HR=0.92, 95%CI=0.88-0.96). The difference was not clinically significant. Selection bias and confounding may explain this unexpected result.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".