Prostate Cancer as a Metabolic Disease - Is Prostate Cancer Diagnosis Associated with Worse Cardiovascular Outcomes?
Bibliographic record
Abstract
Metabolic syndrome (MetS) and prostate cancer (PC) share several risk factors. In addition to increased cardiovascular risk, there is evidence that men with MetS have an increased PC risk. Given that both diseases develop over decades, PC diagnosis may precede the onset of MetS, and may be an early indicator of cardiovascular risk. We sought to determine if PC diagnosis is associated with increased risk of subsequent cardiovascular event. In our population-based study using administrative databases, men with PC identified using the Ontario Cancer Registry were hard-matched and propensity score-matched to men without PC diagnosis identified using the Registered Persons Database. Competing risks analyses were performed to compare risk of cardiovascular events. Contrary to our hypothesis, men with PC were less likely to experience a cardiovascular event compared to men without PC (sub-distributional HR=0.92, 95%CI=0.88-0.96). The difference was not clinically significant. Selection bias and confounding may explain this unexpected result.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".