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Record W2570261935 · doi:10.21037/tlcr.2016.12.08

Rebuttal from Dr. Bezjak and Dr. Giuliani

2016· editorial· en· W2570261935 on OpenAlexaff
Meredith Giuliani, Andrea Bezjak

Bibliographic record

VenueTranslational Lung Cancer Research · 2016
Typeeditorial
Languageen
FieldMedicine
TopicLung Cancer Diagnosis and Treatment
Canadian institutionsPrincess Margaret Cancer Centre
Fundersnot available
KeywordsMedicineRadiological weaponRebuttalMalignancyRadiologySalvage therapyPathologicalLung cancerBiopsyRadiation therapySurgeryOncologyInternal medicineChemotherapy

Abstract

fetched live from OpenAlex

In response to Nguyen and Palma’s submission arguing that radiological suspicion of a local recurrence can be sufficient indication to proceed to salvage therapy, it is clear that despite efforts from several international groups, distinguishing recurrent tumor from radiation induced lung injury (RILI) using radiological evidence, such as CT or FDG-PET scans, is far from an exact science. The authors correctly point out that clinical practice in presumed medically inoperable stage I lung cancer allows for SBRT treatment without biopsy confirmation, for lesions with radiological features strongly suggesting malignancy. However, they are proposing that this approach could be reasonably extended to salvage therapy following SBRT. We contend that the therapeutic ratio, i.e., risk versus benefit, is substantially different for initial SBRT treatment versus post-SBRT salvage treatment, and thus we maintain that pathological proof of recurrence be obtained wherever reasonable.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Insufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Editorial · Consensus signal: Editorial
Teacher disagreement score0.205
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0030.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.042
GPT teacher head0.444
Teacher spread0.402 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designNot applicable
Domainnot available
GenreEditorial

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2016
Admission routes1
Has abstractyes

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