Integrated genomic characterization of oesophageal carcinoma
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Abstract
Oesophageal cancers are prominent worldwide; however, there are few targeted therapies and survival rates for these cancers remain dismal. Here we performed a comprehensive molecular analysis of 164 carcinomas of the oesophagus derived from Western and Eastern populations. Beyond known histopathological and epidemiologic distinctions, molecular features differentiated oesophageal squamous cell carcinomas from oesophageal adenocarcinomas. Oesophageal squamous cell carcinomas resembled squamous carcinomas of other organs more than they did oesophageal adenocarcinomas. Our analyses identified three molecular subclasses of oesophageal squamous cell carcinomas, but none showed evidence for an aetiological role of human papillomavirus. Squamous cell carcinomas showed frequent genomic amplifications of CCND1 and SOX2 and/or TP63, whereas ERBB2, VEGFA and GATA4 and GATA6 were more commonly amplified in adenocarcinomas. Oesophageal adenocarcinomas strongly resembled the chromosomally unstable variant of gastric adenocarcinoma, suggesting that these cancers could be considered a single disease entity. However, some molecular features, including DNA hypermethylation, occurred disproportionally in oesophageal adenocarcinomas. These data provide a framework to facilitate more rational categorization of these tumours and a foundation for new therapies.
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The record
- Venue
- Nature
- Topic
- Esophageal Cancer Research and Treatment
- Field
- Medicine
- Canadian institutions
- Princess Margaret Cancer CentreCanada's Michael Smith Genome Sciences CentreLondon Health Sciences CentreOntario Institute for Cancer ResearchBC Cancer Agency
- Funders
- National Center for Advancing Translational SciencesNational Cancer InstituteNational Human Genome Research InstituteYonsei University College of MedicineNational Institute of Environmental Health SciencesResearch Institute, Nationwide Children's HospitalSchool of Medicine, Indiana UniversityUniversity of Texas MD Anderson Cancer CenterNational Institutes of HealthPeter MacCallum Cancer CentreKeimyung UniversityUniversity of DundeeChonnam National UniversityHospital de Câncer de BarretosBroad InstituteUniversity of WashingtonMemorial Sloan-Kettering Cancer CenterJohns Hopkins UniversityPusan National UniversityLeidosUniversity of PittsburghNationwide Children's HospitalVan Andel Research InstituteWashington University in St. LouisSidney Kimmel Comprehensive Cancer CenterUniversity of RochesterYonsei UniversityUniversity of Southern CaliforniaBC Cancer AgencyVanderbilt UniversityCase Western Reserve UniversityUniversity of North Carolina at Chapel HillBrigham and Women's HospitalEmory UniversityKU LeuvenBrown University
- Keywords
- AdenocarcinomaCancer researchEsophagusPathologyCancerCell of originBiologyCarcinomaCellMedicineInternal medicine
- Has abstract in OpenAlex
- yes