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Efficacy and safety of once-weekly semaglutide monotherapy versus placebo in patients with type 2 diabetes (SUSTAIN 1): a double-blind, randomised, placebo-controlled, parallel-group, multinational, multicentre phase 3a trial

2017· article· en· 707 citations· W2572398654 on OpenAlex· 10.1016/s2213-8587(17)30013-x

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.

Classifier prediction

metacan-v1-d91a1de5be90

Predictions imitate two machine teachers. Scores are not calibrated prevalence probabilities.

Classifier candidate
Randomized trialNon-randomized trial
Classifier consensus
Randomized trial
Teacher imitation scores

Codex

Randomized trial1.000
Meta-analysis0.014
Not applicable0.013
Observational0.002
Metaresearch0.001
Non-randomized trial0.001
Qualitative0.000
Theoretical or conceptual0.000
Other design0.000
Scholarly communication0.000
Simulation or modelling0.000
Bibliometrics0.000
Open science0.000
Meta-epidemiology (broad)0.000
Meta-epidemiology (narrow)0.000
Research integrity0.000
Systematic review0.000
Case report0.000
Science and technology studies0.000
Bench or experimental0.000

Gemma

Randomized trial1.000
Non-randomized trial0.019
Meta-analysis0.005
Theoretical or conceptual0.000
Observational0.000
Qualitative0.000
Not applicable0.000
Simulation or modelling0.000
Bibliometrics0.000
Meta-epidemiology (narrow)0.000
Open science0.000
Research integrity0.000
Scholarly communication0.000
Systematic review0.000
Bench or experimental0.000
Metaresearch0.000
Meta-epidemiology (broad)0.000
Science and technology studies0.000
Case report0.000

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.031
GPT teacher head0.315
Teacher spread
0.284 how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

BACKGROUND

Despite a broad range of pharmacological options for the treatment of type 2 diabetes, optimum glycaemic control remains challenging for many patients and new therapies are necessary. Semaglutide is a glucagon-like peptide-1 (GLP-1) analogue in phase 3 development for type 2 diabetes. We assessed the efficacy, safety, and tolerability of semaglutide monotherapy, compared with placebo, in treatment-naive patients with type 2 diabetes who had insufficient glycaemic control with diet and exercise a…

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