Polysubstituted Isoflavonoids from Spatholobus suberectus, Flemingia macrophylla, and Cudrania cochinchinensis
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Isoflavonoids are a large group of secondary metabolites with diverse biological activities that occur widely in plants, which can be subdivided into isoflavones, isoflavans, isoflavanones, rotenoids, pterocarpans, etc. An overwhelming number of isoflavonoids reported come from the Leguminosae family, and some non-leguminous families such as Moraceae are also relatively abundant in isoflavonoids [ 1 , 2 ]. Some isoflavans and prenylated isoflavones possess potent biological activities, especially in cytotoxicity [ 3 , 4 , 5 , 6 ], anti-inflammatory [ 7 ], and neuroprotective activity [ 8 ]. As part of a BioBioPha ( http://www.chemlib.cn ) objective to assemble a large-scale natural product library valuable in the discovery of new drug leads from nature [ 9 , 10 , 11 , 12 ], the phytochemical investigations on Spatholobus suberectus (Leguminosae), Flemingia macrophylla (Leguminosae), and Cudrania cochinchinensis (Moraceae) led to the isolation of three new isoflavans 7,4′-dihydroxy-8,2′,3′-trimethoxyisoflavan ( 1 ), 7,2′,4′-trihydroxy-8,3′-dimethoxyisoflavan ( 2 ), and 7,2′,4′-trihydroxy-5-methoxyisoflavan ( 3 ), and one new prenylated isoflavone namely cudraisoflavone M ( 4 ), respectively (Fig. 1 ). Herein we report the structure elucidation of new isoflavonoid and their cytotoxicity evaluation against five human cancer cell lines (HL-60, A-549, SMMC-7721, MCF-7, and SW-480).
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it