Top-k utility-based gene regulation sequential pattern discovery
Why this work is in the frame
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Bibliographic record
Abstract
Sequential pattern mining has been used in bioinformatics to discover frequent gene regulation sequential patterns based on time course microarray datasets. While mining frequent sequences are important in biological studies for disease treatment, to date, most of the approaches do not consider the importance of the genes with respect to a disease being studied when identifying gene regulation sequential patterns. In addition, they focus on the more general up/down effects of genes in a microarray dataset and do not take into account the various degrees of expression during the mining process. As a result, the current techniques return too many sequences which may not be informative enough for biologists to explore relationships between the disease and underlying causes encoded in gene regulation sequences. In this paper, we propose a utility model by considering both the importance of genes with respect to a disease and their degrees of expression levels under a biological investigation. Then, we design a new method, called TU-SEQ, for identifying top-k high utility gene regulation sequential patterns from a time-course microarray dataset. The evaluation results show that our approach can effectively and efficiently discover key patterns representing meaningful gene regulation sequential patterns in a time course microarray dataset.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it