In situ titin properties at long lengths when Ig domain folding/unfolding is prevented
Bibliographic record
Abstract
Titin, also known as connectin, is the largest known protein and was discovered in the mid-1970s and consists of Immunoglobulin (Ig) domains that flank N2A and PEVK segments. At long lengths and high force these Ig domains unfold. There is growing evidence that titin may change its stiffness by attaching its proximal portion to actin upon activation. If so folding/unfolding of Ig domains may become physiologically relevant. This is of interest because Ig domain folding/unfolding is associated with a great loss of energy, but preventing such folding/unfolding has been shown to result in a virtually elastic behaviour with no energy loss in isolated titin molecules. Therefore, the purpose of this study was to test titin properties in situ within sarcomeres at lengths where Ig domain unfolding has occurred while preventing folding/unfolding of Ig domains during small stretch shortening cycles.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".