Premature remodeling of fat body and fat mobilization triggered by platelet‐derived growth factor/VEGF receptor in <i>Drosophila</i>
Bibliographic record
Abstract
ABSTRACT In Drosophila, fat‐body remodeling accompanied with fat mobilization is an ecdysone‐induced dynamic process that only occurs during metamorphosis. Here, we show that the activated Drosophila platelet‐derived growth factor/VEGF receptor (PVR) is sufficient to induce shape changes in the fat body, from thin layers of tightly conjugated polygonal cells to clusters of disaggregated round‐shaped cells. These morphologic changes are reminiscent of those seen during early pupation upon initiation of fat‐body remodeling. Activation of PVR also triggers an early onset of lipolysis and mobilization of internal storage, as revealed by the appearance of small lipid droplets and up‐regulated lipolysis‐related genes. We found that PVR displays a dynamic expression pattern in the fat body and peaks at the larval‐prepupal transition under the control of ecdysone signaling. Removal of PVR, although it does not prevent ecdysone‐induced fat‐body remodeling, causes ecdysone signaling to be up‐regulated. Our data reveal that PVR is active in a dual‐secured mechanism that involves an ecdysone‐induced fat‐body remodeling pathway and a reinforced PVR pathway for effective lipid mobilization. Ectopic expression of activated c‐kit—the mouse homolog of PVR in the Drosophila fat body—also results in a similar phenotype. This may suggest a novel function of c‐kit as it relates to lipid metabolism in mammals.—Zheng, H., Wang, X., Guo, P., Ge, W., Yan, Q., Gao, W., Xi, Y., Yang, X. Premature remodeling of fat body and fat mobilization triggered by platelet‐derived growth factor/VEGF receptor in Drosophila. FASEB J. 31, 1964–1975 (2017). www.fasebj.org
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".