Scleral Remodeling in Early Recovery from Induced Experimental Myopia
Bibliographic record
Abstract
PURPOSE: To explore the contribution and impact of fibrous scleral remodeling in the early recovery from lens induced myopia of chicks. METHOD: Refractive error, axial length and histopathological studies were performed on chicks subject to myopic influence with -10 D goggles unilaterally on the day of hatching for a period of 14 days, after which the eyes were enucleated and immediately fixed for histopathological assessment. Three groups, myopia (measurements taken directly after 14 days), early recovery from induced myopia (chicks allowed a three-hour recovery period by removing goggles before analysis) and control (no goggles) were evaluated. The histological slides were assessed with bright field microscopy using Leica image analysis software. RESULTS: Early recovery from induced myopia resulted in a significant increase in the thickness of fibrous sclera to levels twice as high as the ones observed in the control or myopia groups. Histochemical staining revealed three times increase in fibroblast cell count of the early recovery from induced myopia group along with a statistically significant increase in levels of elastin contents relative to the control. However, fibroblast morphometry revealed no difference in maximum cell diameter, perimeter, and area between all experimental groups. CONCLUSION: Recovery from induced experimental myopia results in fibrous scleral remodeling. Significant increase in the scleral thickness is related to heightened cell proliferation and elastic fiber contents. These results indicate that the fibrous sclera is not a passive component in the emmetropization process, but rather plays a significant and active role in the adaptation changes of the eye during early recovery from induced myopia.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".