P742 Arterial stiffness as a marker of vascular aging in IBD patients – a pilot study
Bibliographic record
Abstract
Background: Chronic systemic inflammation can contribute to development of arterial stiffness increase and accelerated vascular aging. Recent research has demonstrated higher risk of developing atherosclerosis in inflammatory bowel disease (IBD). Noninvasive measurement of aortic pulse wave velocity (PWV) has predictive value for future fatal cardiovascular events and total cardiovascular mortality. The aim of our study was to assess the level of arterial stiffness by measuring aortic PWV as an index of arterial stiffness in IBD patients. Methods: We conducted a pilot observational study on a cohort of IBD patients during the period from December 2015 to October 2016. We measured PWV with validated, noninvasive oscillometric device (Tensiomed Arteriograph device (Medexpert Ltd., Budapest, Hungary)) in all patients enrolled in this study. Select laboratory data were collected, as well as patients' medical history relevant for the analysis. Results: A total of 40 patients diagnosed with IBD with median age of 31 years (range: 18–66 yr) were enrolled: 24 Crohn's disease (CD) patients – median age 28.5 yr (range: 18–58 yr, 62% males), and 16 ulcerative colitis (UC) patients – median age 41.5 yr (range: 18–66 yr, 62% males). Mean±SEM PWV value was 8.11±0.35 m/s, 7.83±0.28 m/s, and 8.52±0.78 m/s for IBD, CD and UC groups, respectively. There was no statistically significant difference between the CD and UC in PWV values (p=0.34) nor age (p=0.10). Stricturing (Montreal classification-B2) and penetrating phenotype (B3) of CD were associated with higher PWV values comparing to non-stricturing, non-penetrating phenotype (B1) (8.23±0.43 m/s (n=8) and 8.39±0.6 m/s (n=7) vs 7.03±0.28 m/s (n=9); p=0.033 and p=0.057, respectively). Significant correlation was found between PWV values and patients' age (p<0.0001, r=0.71) and cholesterol levels (p=0.0206, r=0.3649). Also, patients on steroid therapy (n=8) had higher measured PWV values than the ones on immunomodulatory therapy (n=13) (9.29±0.88 m/s vs 7.58±0.42 m/s), although this result did not reach level of statistical significance (p=0.06). Conclusions: According to our data, CD phenotype and patients' age have a significant impact on arterial stiffness in IBD. Higher PWV values in B2 and B3 CD phenotype could be an effect of more profound systemic inflammation in these patients. Also, higher PWV values in steroid therapy subgroup could be related to current disease activity. There seems to be no difference in aortic PWV between CD and UC patients. However, next step in our research is to measure PWV in a larger cohort of patients with a goal to further elucidate the differences within IBD patient groups, according to disease phenotype, disease length and treatment regimens.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".