Bibliographic record
Abstract
Molecules discovered in the “golden age of antibiotics” are increasingly being revisited in an era where new antibiotics are desparately needed. One of these molecules, the bacterial tryptophanyl-tRNA synthetase inhibitor indolmycin, features a unique oxazolinone heterocycle whose biogenetic origins have remained obscure for over 50 years. We have identified and characterized the indolmycin biosynthetic pathway. Our work revealed the decades-long mystery of how the characteristic core oxazolinone ring is assembled from tryptophan- and arginine-derived metabolites. Our efforts have furthermore shown the key role of a gatekeeper enzyme, which acts to re-route metabolites away from a unique shunt product. Our work establishes the complete pathway for indolmycin formation and sets the stage for using genetic and chemo-enzymatic methods to generate new indolmycin derivatives as potential therapeutic agents.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".