LONG TERM IN VIVO KINEMATICS OF THE OVINE STIFLE JOINT FOLLOWING ANTERIOR CRUCIATE LIGAMENT TRANSECTION
Bibliographic record
Abstract
INTRODUCTION Osteoarthritis (OA) is a degenerative joint disease involving the breakdown of articular cartilage, which is common after injury or with aging 1 . Following knee injury, sheep develop OA at a slightly accelerated rate compared to humans but with some similar patterns 2 . In an ovine knee injury model 3,4 , altered gait mechanics and degradation of the cartilage has been observed 20 weeks post anterior cruciate ligament (ACL) transection (Tx) surgery; however, potential alterations in gait at 40 weeks post ACL Tx surgery remain to be determined. Therefore, the objective of this study was to investigate the in vivo kinematics of the ovine stifle joint over time (20 weeks and 40 weeks) following ACL Tx. METHODS Force Plate Testing. Three skeletally mature 3 to 4-year-old female Suffolk-cross sheep (average weight 77.1kg) were led across an embedded force platform (Kistler Instrumente, Winterthur, Switzerland) until 20 hind limb hoof strikes were recorded at 1200 Hz. Peak hind limb vertical ground reaction force was determined prior to surgical plate implantation, and then serially prior to each kinematic data collection. Surgical Procedure. All sheep had a bone plate implanted onto each of the proximomedial aspect of the tibia and the distolateral aspect of the femur of their right hind limb, four weeks prior to kinematic testing. Kinematic Collection and Bone Digitization. On the day of kinematic testing, a stainless steel post was attached to each plate and an instrumented spatial linkage (ISL) mounted between them. The ISL consisted of six rotational encoders providing a measurement of position and orientation in six degrees of freedom (6-DOF) to its motion throughout gait. The in vivo kinematics of the stifle joint were measured while the sheep walked on a treadmill at 2 mph (0.89 m/s). Each sheep then underwent arthroscopic ACL Tx surgery on their right hind limb. The in vivo gait kinematics were measured again over time at 20 and 40 weeks post ACL Tx. Following kinematic testing at 40 weeks, the animals were euthanized. A coordinate measuring machine was used to measure anatomic landmarks on the bone with respect to the ISL in order to create an anatomically relevant coordinate system. Analysis. Data are presented as mean ± SD. RESULTS Figure 1 : The 6-DOF in vivo gait kinematics of the ovine stifle joint, intact (black), 22 weeks post ACL Tx (red), and 40 weeks post ACL Tx (blue). DISCUSSION AND CONCLUSIONS These data indicate that the in vivo kinematics of the ovine stifle joint do change over time following ACL Tx. The kinematic changes appear to be more drastic after 22 weeks, and do not entirely return back to pre-injury mechanics in all rotations and translations after 40 weeks. As shown in Figure 1, the medial-lateral as well as posterior-anterior translation of the joint is progressively altered post ACL Tx over time. Rotationally, the internal-external kinematic curve at 22 weeks is dissimilar to the intact motion, however by 40 weeks a recovery towards the intact measurement is seen as the animal compensates for the injury. In the future, principal component analysis will be utilized to compare these gait changes. In conclusion, the transection of the ACL causes long-term changes in the in vivo kinematics of the joint. Alterations of the kinematics may result in degradation of cartilage due to abnormal loading of the joint and overall damage in the joint due to compensation of the instability post ACL Tx, which is a painful and destructive condition.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".