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Record W2588480453 · doi:10.15436/2377-1348.14.005

Screening of Wilson’s Diseases Effect on the Brain at Exon 8

2015· article· en· W2588480453 on OpenAlexfundno aff
Vanita Pudata

Bibliographic record

VenueInternational Journal of Neurology and Brain Disorders · 2015
Typearticle
Languageen
FieldNursing
TopicTrace Elements in Health
Canadian institutionsnot available
FundersInstitute of GeneticsOsmania University
KeywordsExonMolecular biologyAgarose gel electrophoresisgenomic DNABiologyGeneticsGeneDNAChromosomeMutation

Abstract

fetched live from OpenAlex

Wilson disease (WD) is an autosomal recessive disorder caused by defects in ATP7B gene located on chromosome 13q21.1, and manifested as Hepatolenticular degeneration as a result of accumulation of copper. A total number of 20 control samples were taken for studying the mutations in exon 8. Genomic DNA was prepared from the peripheral blood of the patients. The exon 8 was amplified by PCR using primers. Amplified DNA fragments were analyzed by Agarose gel electrophoresis. Further the patient PCR DNA products will be subjected to Restriction analysis. The results in all controls did not reveal any mutation in the exon 8 of the gene.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.007

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.020
GPT teacher head0.316
Teacher spread0.296 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2015
Admission routes1
Has abstractyes

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