SP302TEMPORAL PATTERN VASCULAR PATHOGENESIS IN CKD: REGIONAL HETEROGENEITY IN VASCULAR CALCIUM ACCRUAL
Bibliographic record
Abstract
Introduction and Aims: Blood vessels have a differential susceptibility to calcification depending on anatomical location. Although vascular calcification (VC) is highly prevalent in patients with chronic kidney disease (CKD), the regional and temporal pattern of calcium deposition across the vasculature has not been elucidated. The study objective was to determine the time course and severity of VC pathology across vascular beds in experimental CKD. Methods: Male Sprague-Dawley rats were maintained on a CKD diet (0.25% adenine) for 3 weeks (n=8, creatinine: 127 ± 66uM), 5 weeks (n=15, creatinine: 391 ± 66uM) and 7 weeks (n=40, creatinine: 268 ± 121 uM). Results: 3 wks of CKD did not yield VC in any vascular bed assessed. However, after 5 and 7 wks on CKD diet respectively: 21% vs. 33% of animals developed VC in the thoracic aorta, 36% vs. 51% in the abdominal aorta, 31% vs. 42% in the carotid artery, and 72% vs. 65% in the internal pudendal artery. These data indicate substantial heterogeneity across vascular beds in their susceptibility to calcification in CKD. To further characterize the pathogenesis of VC, CKD rats (7 wks 0.25% adenine, SD rats) were placed on a low (20 ng/kg/day, n=24, creatinine: 211 ± 63uM) or a high dose of calcitriol (80ng/kg/day, n=24, creatinine: 201 ± 45 uM) to generate a range of VC severity. The animals were grouped into a single cohort and then stratified by the presence of VC in the thoracic aorta. When VC was not yet present in the thoracic aorta, calcium content was already significantly elevated above control levels in the iliac artery (45.9 fold), renal artery (12.6 fold), and internal pudendal artery (12.6 fold; p<0.05). However, when VC was present in the TA, the rank order for the capacity for calcium accumulation (nmol/mg tissue, fold increase above control) was from proximal to distal: thoracic aorta (400x), abdominal aorta (314x), iliac artery (214x), renal artery (118x), internal pudendal artery (64x; p<0.05).
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".