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Record W2588808558 · doi:10.5281/zenodo.7302710

Protective role of flaxseed oil on hypercholesterolemic rats

2022· article· en· W2588808558 on OpenAlexaboutno aff
Mohamed M. Aly-Aldin, E. H. Mansour, Elsayed H. Rahma, Magida M. El-Habashy

Bibliographic record

VenueZenodo (CERN European Organization for Nuclear Research) · 2022
Typearticle
Languageen
FieldNursing
TopicFatty Acid Research and Health
Canadian institutionsnot available
Fundersnot available
KeywordsFood scienceChemistryTraditional medicineBusinessMedicine

Abstract

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ABSTRACT The present study aims to investigate the effects of replacing corn oil content (10%) in the standard diet of hypercholesterolemic rats (fed standard diet + 2% cholesterol for 4 weeks) with 50, 75 and 100% levels of flaxseed oil on the body weight gain, organ weight, blood glucose, liver and kidney functions and lipid profile. Data showed that 2% cholesterol administration caused significant increase in glucose, ALT, AST, ALP, urea, uric acid, triglyceride, total lipids, total cholesterol, LDL and VLDL levels in serum of hypercholesterolemic rats. Body weight gain and organ weight also significantly increased as compared to control rats. Consumption flaxseed oil at different replacement level diets by hypercholesterolemic rats resulted in significant decrease in body weight gain, organ weight and lipid parameters except HDL which decrease as compared to hypercholesterolemic rats fed standard diet. Blood glucose level, liver functions and kidney functions were also improved. Key words: Flaxseed oil, hypercholesterolemic rats, lipid profile, liver functions, kidney functions REFERENCES Al-Bishri, W.M. 2013. Favorable effects of flaxseed supplemented diet on liver and kidney functions in hypertensive rats. Journal of Oleo Science, 62: 709-715. Allian C., Poon L., Richmond W., Fu P. 1974. Enzymatic determination of total serum cholesterol. Clin Chem, 20: 470-475. Anwar M., Meki A. 2003. Oxidative stress in streptozotocin-induced diabetic rats: effects of garlic oil and melatonin. Comparative Biochem Physiol, 135: 539-547. Barakat, L.A.A., Mahmoud, R.H. 2011. The antiatherogenic, renal protective and immunomodulatory effects of purslane, pumpkin and flax seeds on hypercholesterolemic rats. North American Journal of Medical Sciences, 3: 351-357. Barcelo-Coblijn, G., Murphy, E.J. 2009. Alpha-linolenic acid and its conversion to longer chain n-3 fatty acids: benefits for human health and a role in maintaining tissue n-3 fatty acid levels. Progress in Lipid Research, 48:355-374. Barham, D., Trinder, P. 1972. Quantitative enzymatic colorimetric determination of uric acid in serum, plasma or urine. Analyst, 97: 142-145. Burstein, M., Scholnik, H., Morfin, R. 1970. Rapid method for the isolation of lipoproteins from human serum by precipitation with polyphenols. J lipid Res, 11: 583-595. Chapman, D.G., Castilla, R., Campbell, J.A. 1959. Evaluation of protein in foods: 1. A method for the determination of protein efficiency ratios. Canadian J. of Biochemistry and Physiology, 37: 679-686. Cohen S., Moore A., Ward W. 2005. Flaxseed oil and inflammation –associated bone abnormalities in interleukin 10 Knockout mice. The Journal of Nutritional Biochemistry, 16: 368-374. Drury, R.A., Wallington, E.A. 1980. Carton’s Histological Technique, 5th Ed., Oxford Univ. London, U.K. EL-Sahar, E.G.E., Abed EL- Rahman, A.M.M. 2014. Study on the biological effect of use flaxseed oil as a source of fat on the Biomarkers of experimental rats. Journal of American Science, 10: 116-123. El-Sayed, H.H., Darwish A.H., Ysein, E.M., Zehairy G.D. 2014. Biochemical and biological study on the effect of flaxseed on rats Suffer from nephropathy. Journal of Environmental Science, Toxicology and Food Technology, 8: 59-66. FadlAlla, E.A.S., Owiss, N.A., Seddik, A.A., Galal, S.M. 2014. Hypolipidemic, antioxidant and renal protective effect of seeds mixture rich in omega-3 and omega-6 fatty acids in rats. Life Science Journal, 11: 866-877. Faulkner, N.R., King, J.W. 1976. Fundamental of Clinical Chemistry, 2nd Ed., Tietz Editor, Saunders Philadelphia, U.S.A, pp: 994-998. Fernandez, I., Pallaro, A.N., Slobodianik, N.H. 2007. Comparative study between two different sources of n-3 polyunsaturated fatty acids and it effect on thymus and lipid profile in rats. Archivos Latinoamericanos de Nutrición, 57: 146-154. Hayssement, T. U. 1977. Determination of alkaline phosphatase. Clinica Chimica Acta, 35: 271-273. Hussein, S.A., El-Senosi, Y.A., Ragab, M.R., Hammad M.M.F. 2014. Beneficial effect of flaxseed oil on lipid metabolism in high cholesterol diet fed rats. Banha Veterinary Medical Journal, 27: 290‐301. Lecumberri, E., Goya, L., Mateos, R., Alia, M., Ramos, S., Izquierdo-Pulido, M., Brvo, L. 2007. A diet rich in dietary fiber from cocoa improves lipid profile and reduced malondialdehyde in hypercholesterolemic rats. Nutrition 23: 332-341. Lee, R., Nieman, D. 1996. Nutritional Assessment. 2nd Ed. Mosby, Missouri, USA. Likhodii, S.S., Musa, K., Mendonca, A., Dell, C., Burnham, W.M., Cunnane, S.C. 2000. Dietary Fat, Ketosis, and Seizure Resistance in Rats on the Ketogenic Diet. Epilepsia, 41: 1400-1410 Patton, C. J., Crouch, S. R. 1977. Enzymatic colorimetric method for determination of urea in serum. Anal. Chem., 49: 464-469. Prasad, K. 2000. Flaxseed: a source of hypocholesterolemic and antiatherogenic agents. Drug News Perspect, 13: 99-102. Rahman, M.M., Pharm, B., Pharm, M., Mazid, M.A., Islam, S.N. 2014. Hypercholesterolemic effects of fish and vegetable oils on the serum lipid profile of experimentally induced hypercholesterolemic rats. European Scientific Journal, 10:476-482. Rangrej, V., Shah, V., Patel, J., Ganorkar, P.M. 2015. Effect of shortening replacement with flaxseed oil on physical, sensory, fatty acid and storage characteristics of cookies. J Food Sci Technol, 52: 3694-3700. Rasmy, G. E. 2007. Protective Effect of Linseed Oil on Hyperlipidemia in Experimental Animals. Journal of Genetic Engineering and Biotechnology, 5: 9-17. Reeves, P.G., Nielsen, F.H., Fahey, G.C. Jr. 1993. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. Journal of Nutrition, 123:1939-1951. Reitman, S., Frankel, S. 1957. Determination, of alanine aminotranspherase and aspartate aminotranspherase. Amer. J. of Clin. Path., 28: 57-63. Schermer, S. 1967. The Blood Morphology of Laboratory Animals. Green and Co., Ltd., Longmans, pp: 350-355. Shah, P.K., Kaul, S., Nilsson J., Cercek, B. 2001. Exploiting the vascular protective effects of high density lipoprotein and its apolipo proteins: an idea whose time for testing is coming. Circulation, 104: 2376-2383. Trinder, P. 1969. Enzymatic determination of glucose. Ann. Clin. Biochem., 6: 24-29. Tzang, B.S., Yang, S.F., Fu, S.G., Yang, H.C., Sun, H.L., Chen, Y.C. 2009. Effects of dietary flaxseed oil on cholesterol metabolism of hamsters. Food Chemistry, 114:1450-1455. Wahlefeld, A.W. 1974. Enzymatic Determination of Triglycerides. Methods of Enzymatic Analysis. 5th HU. Bergmeyer, Ed. Academic Press, New York, USA, pp: 1831-1835. Zollner N., Kirsch K. 1962. Microdetermination of lipids by the Sulphophospho vanillin reaction. Z Ges Exp Med, 135: 545-561.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.006

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.030
GPT teacher head0.262
Teacher spread0.232 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

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Citations12
Published2022
Admission routes1
Has abstractyes

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