Caspases play in traffic
Bibliographic record
Abstract
The unfolding of apoptosis involves the orchestrated proteolysis of hundreds of proteins, 1 and to achieve efficacy the cell has evolved a three-step activation cascade. First, initiator caspases (caspases 8, 9, 10) are activated either by external death ligands triggering the formation of the death-inducing signaling complex (DISC; caspases 8 and 10) or by the release of cytochrome c from mitochondria provoking the assembly of the apoptosome (caspase-9). 2 Once activated, the initiator caspases directly cleave executioner caspases 3 and 7, leading to their activation. The third step is the caspase-3-mediated activation of the executioner caspase-6, a peptidase with a substrate preference similar to that of initiator caspases. In this manner, the cell amplifies the proteolytic activity of caspases to swiftly cause cell demise. 2
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".