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Record W2592087829 · doi:10.15562/diabesity.2017.37

The potential of mesenchymal stem cells in diabetes mellitus

2017· article· en· W2592087829 on OpenAlexvenueno aff
Narasimman Gurusamy

Bibliographic record

VenueDiabesity · 2017
Typearticle
Languageen
FieldMedicine
TopicPancreatic function and diabetes
Canadian institutionsnot available
Fundersnot available
KeywordsMedicineDiabetes mellitusMesenchymal stem cellInsulinClinical trialStem cellPopulationInternal medicineType 2 Diabetes MellitusIntensive care medicineEndocrinologyPathologyBiologyEnvironmental health

Abstract

fetched live from OpenAlex

While exogenous insulin and oral hypoglycemic agents are helpful in controlling the blood glucose level in diabetic patients, these agents are occasionally resulted in hypoglycemic coma. Considering the epidemiology of the diabetic population in the world, we require a better therapeutic strategy like expanding the existing beta- cells within the body or by supplying exogenous insulin-producing stem cells. A variety of stem cells have been tested for the treatment of type 1 and type 2 diabetes mellitus, and among them, mesenchymal stem cells (MSCs) are widely used because of their immunomodulatory and low-immunogenic characteristics. So far, eight clinical trials have been completed using MSCs for the treatment of diabetes mellitus. Although the results of the currently available clinical trials are encouraging, i.e. in improving function of the pancreatic beta cells and in controlling the complications associated with diabetes, we require larger, randomized, and double-blinded studies, with a longer duration of follow-up, to validate the findings obtained.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: none
Teacher disagreement score0.002
Threshold uncertainty score0.006

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0000.000
Scholarly communication0.0010.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.013
GPT teacher head0.241
Teacher spread0.228 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designTheoretical or conceptual
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2017
Admission routes1
Has abstractyes

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