Manganese scavenging and oxidative stress response mediated by type VI secretion system in <i>Burkholderia thailandensis</i>
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Significance As an essential micronutrient, Gram-negative bacteria must concentrate Mn 2+ into the cytosol via active transport systems to meet cellular demands. Whereas inner membrane Mn 2+ transporters have been characterized, an active transporter for translocation of Mn 2+ across the outer membrane has not been described. Here we report a Mn 2+ -scavenging pathway consisting of a newly identified TonB-dependent outer membrane manganese transporter, MnoT, and a type VI secretion system (T6SS)-secreted Mn 2+ -binding protein, TseM. Traditionally, T6SS is recognized as a contact-dependent nanomachine to inject effectors into eukaryotic or prokaryotic cells for virulence or for interbacterial competition. The contact-independent functions of T6SS for metal acquisition and bacteria–bacteria competition, reported here, suggest that T6SS may have been retrofitted by some bacteria to gain additional adaptive functions during evolution.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it