Abstract 368: Increased Platelet Activity in HIV-Infected Subjects on Antiretroviral Therapy Is Inhibited with Low-Dose Aspirin
Bibliographic record
Abstract
Introduction: HIV-infected adults are at increased risk for cardiovascular events and increased platelet activity may contribute to this risk. Hypothesis: Platelet activity measurements are increased in subjects with HIV on fully suppressive antiretroviral therapy (ART) and low-dose aspirin attenuates this increase in platelet activity. Methods: We studied platelet aggregation in 25 HIV infected subjects on ART with undetectable plasma HIV-1 RNA and median CD4 521 cells/mm 3 and 29 healthy HIV seronegative controls in response to submaximal adenosine diphosphate (ADP, 0.4uM), collagen (0.05ug/ml), epinephrine (0.1uM ), arachidonic acid (AA, 0.15mM) and without agonist (spontaneous platelet aggregation [SPA]). The effects of a 1-week course of aspirin 81mg daily on platelet activity were also investigated. Results are presented as median (interquartile range) and analyzed using the Mann-Whitney U test. Results: Compared to controls, subjects with HIV had increased platelet aggregation in response to ADP (13.5% [6.8, 81.6] vs 6.4% [2.8, 10.7], p<0.01), collagen (13.5% [6.8, 81.6] vs 6.4% [2.8, 10.7], p=0.01), AA (81.9% [9.4, 90.2] vs 9.6% [2.8, 77], p<0.01), and SPA, 8.2% [4.7, 13.2] vs 4.5% [2.2, 8.9], p=0.04). There was no difference in baseline aggregation in response to epinephrine. Following aspirin therapy, percent aggregation in response to AA decreased more in subjects with HIV (-43% vs -20%, P=0.04), yet remained significantly higher in subjects with HIV versus controls (9.8% [5.8, 16.6] vs 7.4 [4.4, 9.8], P=0.02). In response to ADP, collagen, epinephrine, and SPA, subjects with HIV experienced numerically greater platelet inhibition than controls and residual platelet aggregation was not significantly different between groups. Conclusions: Baseline platelet activity is increased in subjects with HIV infection virologically suppressed on ART which may contribute to the excess cardiovascular risk commonly observed in this population. Subjects with HIV experienced greater decreases in platelet activity in response to aspirin, retaining modestly more platelet activity compared to controls. Cardiovascular prevention studies of aspirin in subjects with HIV are warranted.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".