Role of H2 relaxin in the human thyroid
Bibliographic record
Abstract
The multifunctional peptide hormone relaxin has recently been identified as an important endocrine player in tumor biology. We found H2 relaxin to be exclusively expressed in human papillary, follicular and dedifferentiated thyroid carcinoma but not in hyperplastic or normal human thyroid tissues. To investigate the role of H2 in thyroid carcinoma cells, we have generated and characterized stable H2 secreting transfectants of the human follicular thyroid carcinoma cell lines FTC-133. Microarray analysis of the FTC-133 transfectants revealed changes in gene expression of enzymes affecting extracellular matrix (ECM) composition indicating a potential role of H2 relaxin in thyroid carcinoma invasiveness. Exposure to H2 resulted in significantly increased motility of both FTC cells and H2 transfectants demonstrating a role for H2 as an auto-/paracrine migratory factor. When compared with controls, H2 stable FTC-133 transfectants showed differential production as well as altered intracellular distribution and secretion of the lysosomal protease cathepsin L. This is the first demonstration of a novel role of H2 relaxin as a modulator of the cathepsin system. H2 relaxin appears to exert its effects on these highly potent ECM-degrading lysosomal proteases at multiple cellular levels which may attribute to increased motility and tissue invasion of thyroid carcinoma cells. Current studies aim at identification the cellular mechanisms leading to altered lysosomal distribution/secretion and the analysis of additional genes associated with ECM-degradation.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".