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Record W2597772469 · doi:10.21037/atm.2017.02.14

On the function and heterogeneity of extracellular vesicles

2017· letter· en· W2597772469 on OpenAlex
Bernd Giebel

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

fundA Canadian funder is recorded on the work.
no affNo Canadian affiliation: this work is invisible to an affiliation-only frame.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.

Bibliographic record

VenueAnnals of Translational Medicine · 2017
Typeletter
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicExtracellular vesicles in disease
Canadian institutionsnot available
FundersEuropean Regional Development FundUniversität Duisburg-EssenEuropean CommissionVolkswagen FoundationStem Cell Network
KeywordsExtracellular vesiclesFunction (biology)VesicleExtracellularChemistryComputational biologyBiologyCell biologyBiochemistry

Abstract

fetched live from OpenAlex

Both, prokaryotic and eukaryotic cells contain the ability to communicate with cells in their environment. Classically, intercellular cell communication was thought to be mainly mediated by direct cell-cell contacts and by soluble factors including cytokines, growth factors and hormones. In 1996 Raposo and colleagues showed that intercellular communication can also be mediated by vesicles; specifically they reported that B lymphoblastoid cells release MHC class II carrying vesicles which are able to induce antigen-specific MHC class II-restricted T cell responses (1). Since then, an exponentially increasing amount of studies demonstrates the importance of extracellular vesicle (EV) mediated intercellular signaling in a huge variety of different cellular systems and organisms ranging from bacteria and yeast to plants and humans. It became evident that EV-mediated intercellular communication is essentially involved in many physiological and pathophysiological processes (2). Thus, EV-mediated intercellular communication provides a third, very complex mode of intercellular communication. Unraveling the basic principles of this novel intercellular communication system and gaining insight in its complexity will for sure have large impacts on the overall understanding of biological processes and certainly will pave the way for novel diagnostic and therapeutic approaches (2-4).

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.576
Threshold uncertainty score0.554

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.058
GPT teacher head0.313
Teacher spread0.255 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it