Simulation of Propagation of Action Potentials in Cardiac Tissue with an Inhomogeneous Distribution of Extracellular Potassium
Bibliographic record
Abstract
We report simulation of experimental data for heterogeneous distribution of extracellular potassium, by developing and applying a mathematical model formulated by incorporating a Luo-Rudy representation of the cell membrane current into the bidomain model of the cardiac tissue. Our model serves to examine propagation of extra cellular potassium from a region of low potassium (normal) to a region of high potassium (ischemic). Starting with computer simulation of unipolar stimulation of cardiac tissue, we reproduced results of the passive bidomain model, and also simulated the space-clamped Luo Rudy model. Finally, we combined the Luo-Rudy model with the bidomain model. The diastolic threshold for anodal stimulation first decreased and then increased with increasing potassium concentration ([K]0), reaching a minimum value at [K]0=12mM.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".