Phosphorylation-dependent structural changes in the N-terminal extension of SUR2A NBD1
Bibliographic record
Abstract
ATP-sensitive potassium (KATP) channels are involved in many biological processes and play an important role in sustaining healthy functioning organs. KATP channels are composed of four copies of a pore-forming Kir6.x protein that is surrounded by four copies of regulatory sulfonylurea receptor (SUR) proteins. SUR proteins are members of the ATP-binding cassette (ABC) superfamily. Nucleotide binding and hydrolysis at the SUR proteins results in channel opening, which is potentiated by SUR protein phosphorylation. The studies conducted during this thesis aimed to understand how phosphorylation of the N-terminal extension (N-tail) of the first nucleotide binding domain (NBD1) of SUR2A alters its structure and influences the N-tailâ s interaction with the core NBD1. This biophysical study utilizes nuclear magnetic resonance (NMR) and other biophysical techniques to understand these structural and dynamic changes in N-tail with phosphorylation which will allow us to further understand ATP-binding at NBD1 and control of KATP channel conductance.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".