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Record W2601463391

Spontaneous regression of pancreatic cancer

2004· article· en· W2601463391 on OpenAlexaff
Stephen A. Hoption Cann, Hal Gunn, Johannes P. van Netten, Christiaan van Netten

Bibliographic record

Venuenot available
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicCancer Research and Treatments
Canadian institutionsUniversity of VictoriaUniversity of British Columbia
Fundersnot available
KeywordsMedicinePancreatic cancerRegressionCancerInternal medicineOncologyStatistics
DOInot available

Abstract

fetched live from OpenAlex

Background: Spontaneous tumor regression has been the object of considerable interest and speculation for hundreds, if not thousands of years. It has been reported following a wide diversity of infec-tions. We describe a case of spontaneous pancreatic cancer regression and review the relevant literature. Case report: A 50-year-old male presented with a history of weight loss, anorexia and discomfort after meals. Oncology workup revealed pancreatic adenocarcinoma (T2N1M0, stage IIIb). A two-week regimen of radiotherapy combined with seven weeks of gemcitabine failed to alter the progress of the disease. However, a subsequent perforated duodenal ulcer was followed by severe peritonitis, fever, and tumor regression. Conclusions: A review of the literature uncovered only three previous cases of spontaneous pancreatic can-cer regression. The authors discuss the importance of the acute febrile immune response, which appears to be an underappreciated mediator of tumor regression. Key words: fever•infection•leukocytes•pancreatic neoplasms•spontaneous regression

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.010
Threshold uncertainty score0.250

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.011
GPT teacher head0.307
Teacher spread0.296 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations12
Published2004
Admission routes1
Has abstractyes

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