Largest study to date shows overall use of antipsychotics in pregnancy does not appear to significantly increase the risk of congenital malformations
Bibliographic record
Abstract
Atypical and typical antipsychotics (APs) are used to treat bipolar and psychotic disorders, and atypicals are increasingly used off-label to treat other disorders. 1With the rise of their use during pregnancy, we are increasingly in need of high-quality data to rely on for treatment recommendations as data from randomised controlled trials (RCT) are not available.Previous research on whether APs are associated with an increased risk of congenital malformations (CMs) has not yielded consistent findings and has relied on a small number of exposures. [2][3]][4] Given the small baseline risk for CMs in the general population and the large number of potential confounders, very large sample sizes are needed in observational studies assessing the link between APs and CMs.e7
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".