Dexmedetomidine attenuates acute paroxysmal sympathetic hyperactivity
Bibliographic record
Abstract
// Yuan Peng 1, * , Haifeng Zhu 2, * , Haodong Chen 3, * , Zijin Zhu 4, * , Huahai Zhou 5, * , Shuguang Zhang 1, * , Lili Gao 2 , Lei Shi 1, * , Xiaoliang Li 1 and Zhengxiang Luo 6 1 Department of Intensive Care Unit and Neurosurgery, The First People’s Hospital of Kunshan Affiliated with Jiangsu University, Suzhou 215300, P. R. China 2 Department of Neurosurgery and Medical Oncology, Jiangsu Funing People’s Hospital, Funing 224400, P. R. China 3 Department of Neurosurgery, Liuhe Hospital Affiliated to Medical College of Yangzhou University, Nanjing 211500, P. R. China 4 Department of Neurosurgery, Anhui Province Wangjiang Hospital, Anhui 246200, P. R. China 5 Department of Neurosurgery, Sihong County People’s Hospital, Suqian 223900, P. R. China 6 Department of Neurosurgery, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing 210029, P. R. China * These authors have contributed equally to this work Correspondence to: Zhengxiang Luo, email: zhengxiang_luo@126.com Keywords: dexmedetomidine, propofol, paroxysmal sympathetic hyperactivity, prognosis Abbreviations: PSH, paroxysmal sympathetic hyperactivity; α 2 -AR, α 2 -adrenoceptor; GCS, Glasgow Coma Scale; PAID, paroxysmal autonomic instability with dystonia Received: February 13, 2017     Accepted: March 20, 2017     Published: April 07, 2017 ABSTRACT We evaluated the curative effect of dexmedetomidine on paroxysmal sympathetic hyperactivity (PSH) in a retrospective study of 72 PSH patients after neurosurgery. Our results showed that dexmedetomidine was superior to propofol for treatment of PSH with respect to: average time needed to reduce paroxysmal hypertension (PH) to <140/90 mmHg (29.03±8.86 vs. 42.0±14.77 min), average remission time of PH (3.97±1.73 vs. 5.65±1.51 min), PH remission rate (61.22±10.8% vs. 41.52±14.15%), PH duration (9.31±2.66 vs. 13.05±4.19 days), average time for body temperature to return to normal (10.62±4.14 vs. 15.31±4.58 days), average time for heartrate to return to normal (11.34±3.90 vs. 15.72±4.10 days), and average time of respiratory rate below 25 breaths per minute (BPM) (7.00±1.74 vs. 15.32±5.87 days). Multiple logistic regression analyses showed that dexmedetomidine did not protect against the recurrence of PSH. Age and Glasgow Coma Score were the main factors predicting PSH recurrence. There was no difference in Glasgow Outcome Score (GOS) between the two groups during the 6 months of postoperative follow-up ( p >0.05). These data suggest dexmedetomidine effectively controls an acute attack of PSH, but it does not improve the long-term prognosis of patients compared with propofol.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".