MP19-10 IDENTIFICATION OF NEW URINARY RISK MARKERS FOR URINARY STONE PATIENTS USING LOGISTIC MODEL AND MULTINOMIAL-LOGIT MODEL
Bibliographic record
Abstract
demonstrated that daily H 2 S treatment can reduce the histopathological markers of renal injury following 30 days of unilateral ureteral obstruction (UUO).The current study employs UUO followed by reimplantation to investigate the effects of daily H 2 S on renal function following the relief of obstruction.METHODS: The left ureter of male Lewis rats were ligated at the ureterovesical junction.Starting on post-operative day (POD) 1 and every day for 13 days, rats received either daily intraperitoneal (IP) injection of phosphate buffered saline (PBS) vehicle or 200mmol/kg of GYY4137 (slow-releasing H 2 S donor) in PBS.On POD 14, the ligature was removed and the left ureter was reimplanted into the bladder, and a right nephrectomy performed so that the rat is solely dependent on the left kidney.Urine and serum samples were collected to monitor renal function.On POD 30, the left kidney was removed and tissue sections were stained with hematoxylin and eosin (H&E) to measure cortical thickness.RESULTS: 67% of control rats, compared to 100% of H 2 Streated rats, lived until POD 30.Histological analysis showed a significant decrease in cortical thickness (P<0.0001) in control rats when compared to Sham rats, which was significantly rescued upon treatment with H 2 S (P<0.0001).Serum creatinine (SCr) in control rats, but not H 2 S-treated rats, was significantly increased when compared to Sham animals on POD 3 and 7 (P<0.05).Following reimplantation (PODs 17, 21, 24 and 30), SCr in both control and treatment groups were significantly elevated when compared to Sham.Interestingly, H 2 S treatment drastically decreased SCr levels when compared to control animals on all PODs after reimplantation.Proteinuria continued to be higher in both control and treatment groups following reimplantation compared to Sham (P<0.05),however, H 2 S treatment group showed markedly reduced proteinuria compared to the control group.CONCLUSIONS: We show, for the first time, that daily H 2 S therapy rescues renal function and preserves renal architecture following UO.H 2 S may one day become a clinically viable pre-emptive therapy against renal injury associated with UO and contribute to improved renal function in patients with UO.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.007 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.003 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.009 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".