4-1BB (CD137) and radiation therapy: A case report and literature review
Bibliographic record
Abstract
SummaryThere has yet to be any clinical case studies demonstrating the efficacy, safety, and response of combined therapy with 4-1BB agonists and radiation. This report provides the first case of immune costimulatory directed therapy potentially augmented with RT after progression of disease despite several treatments with immunotherapy. Based on preclinical data and results presented in this case, radiation combined with 4-1BB agonists may have a unique and potent effect in addition to other therapies. There has yet to be any clinical case studies demonstrating the efficacy, safety, and response of combined therapy with 4-1BB agonists and radiation. This report provides the first case of immune costimulatory directed therapy potentially augmented with RT after progression of disease despite several treatments with immunotherapy. Based on preclinical data and results presented in this case, radiation combined with 4-1BB agonists may have a unique and potent effect in addition to other therapies.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.006 | 0.004 |
| Science and technology studies | 0.002 | 0.002 |
| Scholarly communication | 0.002 | 0.005 |
| Open science | 0.002 | 0.002 |
| Research integrity | 0.007 | 0.004 |
| Insufficient payload (model declined to judge) | 0.006 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".