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A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection

2017· article· en· W2605345574 on OpenAlexafffund
Xin Niu, Hetal Brahmbhatt, Philipp Mergenthaler, Zhi Zhang, Jing Sang, Michael Daude, Fabian G. R. Ehlert, Wibke E. Diederich, Eve Wong, Weijia Zhu, Justin Pogmore, Jyoti Prokash Nandy, Satyanarayana Maragani, Ravikumar Jimmidi, Prabhat Arya, Brian Leber, Jialing Lin, Carsten Culmsee, Jing Yi, David W. Andrews

Bibliographic record

VenueCell chemical biology · 2017
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicCell death mechanisms and regulation
Canadian institutionsSunnybrook Health Science CentreOntario Institute for Cancer ResearchUniversity of TorontoMcMaster University
FundersNational Institute of General Medical SciencesCanadian Institutes of Health ResearchPresbyterian Health FoundationScience and Technology Commission of Shanghai MunicipalityShanghai Municipal Education CommissionCharité – Universitätsmedizin BerlinOntario Institute for Cancer ResearchCouncil of Scientific and Industrial Research, IndiaNational Institutes of HealthTerry Fox Research InstituteOklahoma Center for the Advancement of Science and TechnologyBerlin Institute of Health
KeywordsCell biologyProgrammed cell deathSmall moleculeApoptosisNeuroprotectionExcitotoxicityBiologyChemistryBcl-2-associated X proteinBiochemistryCaspase 3Pharmacology

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.468

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.011
GPT teacher head0.224
Teacher spread0.212 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations93
Published2017
Admission routes2
Has abstractno

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