MEMS Stabilized Lipid Membranes and Their Parylene Encapsulation
Bibliographic record
Abstract
Planar lipid membranes composed of egg phosphatidylcholine and 1, 2-dioleoyl-sn-glycero-3-phosphocholine were suspended over arrays of 100, 75, and 30 μm diameter holes in a 3.7-mm-thick polyimide or 2-μm-thick Parylene film that was supported on a silicon frame. Membranes were allowed to thin in buffer and periodically examined in air with reflected light microscopy. Once the membranes approached the thickness of a bilayer, they were vapor coated with 80 nm of conformal Parylene. The Parylene coating essentially fixed the membranes indefinitely for further study via optical microscopy, scanning electron microscopy, energy dispersive x-ray spectroscopy, atomic force microscopy, white-light interferometry, and confocal microscopy. This paper demonstrated that lipid membranes suspended on microfabricated hole arrays lasted over six days in buffer and that thinning membranes go through a phase where the lipids form lamellar stacks of bilayers within the holes. A technique for encapsulating the suspended membranes in Parylene was demonstrated that enabled detailed measurements of membrane geometry and composition.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".