9. Congenital Lymphocytic Choriomeningitis Virus: A Neuropathological Study
Bibliographic record
Abstract
Lymphocytic choriomeningitis virus (LCMV) carried and secreted by mice, infects great numbers of people. LCMV infection acquired during childhood or adulthood is usually moderately symptomatic with a full recovery. When the infection occurs prenatally, it results in a wide spectrum of severe brain lesions described mainly on imaging. Neuropathological data have never been reported. We present 2 fetuses with a prenatal diagnosis of microcephaly with ventriculomegaly, abnormal gyration, and ponto-cerebellar hypoplasia in one case. Parents elected to terminate the pregnancy. A complete autopsy demonstrated no dysmorphic features, no visceral or skeletal malformation. Histological examination of viscera did not show any significant lesion. Neuropathological examination confirmed microcephaly and ventriculomegaly with a thick yellowish band surrounding the ventricles. Identical histological lesions were observed in both cases associating a polymicrogyria and a diffuse necrosis of parenchyma with massive calcifications all around the ventricles. The most characteristic feature was the unusual aspect of necrosis, distinct from that observed in other infections, characterized by a finely granular appearance looking like sand. Small lymphocytic infiltrates were observed in the leptomeninges and in the choroid but not in the retina. The congenital LCMV infection was confirmed by serologic testing. This study confirms the strong neurotropism of LCMV and demonstrates that prenatal infection has some particular features such as absent systemic signs, and distinct appearance of the necrosis that allow to distinguish it from other congenital infections and other non infectious conditions.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".