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Record W2607115439 · doi:10.1016/j.eururo.2017.03.021

An Oncofetal Glycosaminoglycan Modification Provides Therapeutic Access to Cisplatin-resistant Bladder Cancer

2017· article· en· W2607115439 on OpenAlexafffund
Roland Seiler, Htoo Zarni Oo, Davide Tortora, Thomas Mandel Clausen, Chris Kedong Wang, Gunjan Kumar, Marina Ayres Pereira, Maj Sofie Ørum-Madsen, Mette Ø. Agerbæk, Tobias Gustavsson, Mie A. Nordmaj, Jamie R. Rich, Nada Lallous, Ladan Fazli, Sherry S. Lee, James J. Douglas, Tilman Todenhöfer, Shaghayegh Esfandnia, Dulguun Battsogt, John S. Babcook, Nader Al-Nakouzi, Simon J. Crabb, Igor Moskalev, Bernhard Kiss, Elai Davicioni, George N. Thalmann, Paul S. Rennie, Peter C. Black, Ali Salanti, Mads Daugaard

Bibliographic record

VenueEuropean Urology · 2017
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicProteoglycans and glycosaminoglycans research
Canadian institutionsGenome British ColumbiaZymeworks (Canada)University of British Columbia
FundersH. Lundbeck A/SLundbeckfondenProstate Cancer Canada
KeywordsMedicineCisplatinOncofetal antigenBladder cancerOncologyInternal medicineCancer researchCancerChemotherapyImmunotherapy

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.789
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0010.000
Scholarly communication0.0000.000
Open science0.0020.001
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.061
GPT teacher head0.382
Teacher spread0.321 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations52
Published2017
Admission routes2
Has abstractno

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