The Armanni-Ebstein Lesion and the Postmortem Diagnosis of Ketoacidosis
Bibliographic record
Abstract
The diagnoses of ketoacidosis and disturbances of glucose metabolism are difficult at autopsy because of changes in glucose concentrations postmortem. The Armanni-Ebstein lesion is a histological change in the kidney that has been reported as a marker of diabetic ketoacidosis. This paper examines the specificity of the Armanni-Ebstein lesion and the diagnosis of alterations in glucose metabolism and ketoacidosis at autopsy. The Armanni-Ebstein lesion consists of subnuclear vacuolation of the proximal tubules. The vacuoles contain fat and can be demonstrated on fresh and formalin fixed tissue using standard fat stains. Recently it has been reported in other conditions associated with non-diabetic ketoacidosis. The lesion has the same appearance whatever the cause of the ketoacidosis. This review, with illustrative cases shows the Armanni-Ebstein lesion is a marker of ketoacidosis and not specific for diabetic ketoacidosis. It may be seen in cases of diabetic and alcoholic ketoacidosis and in starvation and hypothermia, in which ketoacidosis occurs. It has also been reported in isopropanol poisoning.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.003 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".