0289 CARDIOVASCULAR AUTONOMIC DYSFUNCTION IN PATIENTS WITH INSOMNIA AND OBJECTIVE SHORT SLEEP DURATION
Bibliographic record
Abstract
Objective sleep duration has been proposed as a biological marker of insomnia severity. Based on this conceptualization, two phenotypes have emerged. Insomnia with near-normal sleep duration (NNSD) appears to be related to increased psychological symptoms. Conversely, insomnia with short sleep duration (SSD) is associated with an increased risk of future cardiovascular morbidity. Reduced heart rate variability (HRV) has also been implicated in the pathophysiology of cardiac conditions; however, there is little data on whether this physiological marker of cardiovascular function differs based on sleep duration in chronic insomnia patients. Participants were 189 adults (Mage = 49.8 years, SD = 11.8; 63.5% female) who met diagnostic criteria for insomnia. Objective sleep duration was based on total sleep time averaged across two consecutive nights of polysomnography (PSG). The sample was divided into two groups based on sleep duration - shorter (n = 48) or longer (n = 141) than 6 hours. Electrocardiogram data (2-min epochs) derived from PSG were edited and analyzed to obtain HRV during N2, N3, and rapid-eye movement (REM) sleep. HRV measures included high frequency (HF), an index of parasympathetic activation, and the ratio of low to high frequency (LF/HF ratio), an index of sympathovagal balance. Compared to insomnia patients with NNSD, those with SSD had significantly reduced HF-HRV during N2 (45.2 vs. 40.8, p<.001) and REM sleep (34.1 vs. 32.2, p=.007). Additionally, insomnia patients with SSD had significantly greater LF/HF ratio during N2 (1.12 vs. 1.06, p=.002) and REM sleep (1.26 vs. 1.21, p=.009) compared to insomnia patients with NNSD. No significant differences in N3 were found between phenotypes. Overall, insomnia patients with objective SSD showed significantly dampened parasympathetic activation and elevated sympathovagal imbalance relative to their counterparts with NNSD. It is posited that the pathophysiological responses related to short sleep may exacerbate a nocturnal stress response, expediting the progression of cardiovascular morbidity. These findings highlight the importance of treating insomnia, as treatment may reduce risk of cardiovascular disease. Supported by National Institute of Mental Health Grant (RO1MH079188 & R01MH60413) and by the Fonds de recherche du Québec - Santé (32207).
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".