The effects of B vitamins on pain relief and improving physical function in patients with medial compartment knee osteoarthritis
Bibliographic record
Abstract
The effects of B vitamins on pain relief and improving physical function in patients with medial compartment knee osteoarthritis Alireza Amani*1, Farshad Safdari2, Saeed Changizi Ashtiyani3 and Ali Aalizadeh4 ABSTRACT The anti-inflammatory and analgesic effects of B vitamins have been already demonstrated. It seems that these agents are effective in treating knee osteoarthritis (KOA), which is associated with an inflammatory status of the joint. However, the available documents showing the efficacy of these vitamins are so limited. In the current study,we investigated the effects of B vitamins on pain relief and function improvement in patients with KOA. Sixtypatients with mild to moderate KOA were randomly divided into two equal groups of celecoxib (control) and celecoxib with B vitamins (neurobion). Patients were treated for two months. Before and after the treatment, patients' pain intensity and function were measured using visual analogue scale (VAS) and Western Ontario and McMaster Universities Arthritis Index (WOMAC) respectively. On the last visit, the pain intensity significantly decreased and WOMAC scores significantly increased in both groups, respectively (p<0.001). However, the WOMAC scores were the same in both groups , while the pain intensity was significantly lower in neurobion groupon the last visit (p<0.001). Our findings showed that prescribing B vitamins can effectively exacerbate the analgesic effect of celecoxib in patients with KOA without any complications. Keywords: Osteoarthritis, Knee, Pain, B Vitamins, Celecoxib
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".