0302 NOCTURNAL BLOOD PRESSURE AND HEART RATE IN NORMOTENSIVE INSOMNIA PATIENTS
Bibliographic record
Abstract
While sleep-wake cycles are known to affect cardiovascular functions, there is little information on nocturnal blood pressure (BP) and heart rate (HR) in patients with chronic insomnia. Given that insomnia is a risk factor for hypertension, the aim of the present study was to explore BP and HR patterns over the course of the night in normotensive patients with chronic insomnia. Fourteen adults (Mage = 37.5 ± 12.3 years old; 71.4% women, IMC = 24.2 ± 4.9) with chronic insomnia participated in this study. They underwent two nights of baseline ambulatory polysomnography (PSG) using standard montage. In addition, pulse transit time (PTT) and EKG beat-to-beat measures via three-lead EKG were measured continuously throughout the night to obtain blood pressure (systolic and diastolic; SBP, DBP) and HR, respectively. Using data from the second PSG night, sleep was visually scored (WAKE, N1, N2, N3 and REM) and divided into three sleep periods (first, middle, last) throughout the night. The lowest DBP and SBP values were observed during N2 compared to other sleep stages (mean DBP: 72.2 vs 72.7–75.2, p<.0001; mean SBP: 113.9 vs 115–116.5, p =.01), and during the last sleep period (DBP 71.5 vs 72.8–74.5; p=.0007; SBP 112.4 vs113.6–116.9; p=.004). SBP was also significantly reduced in N3 during the middle sleep period (111.5 vs 112.8–115.3, p=.003). Similarly, HR was lowest during N2 (62.6 vs 64.4–69.0, p<.0001), especially during the middle sleep period (63.2 vs 65.1–67.5, p=.004). HR during REM sleep was lower during the late compared to early sleep periods (63.3 vs 65.4–66.9, p=0.02). The lowest values for BP and HR were obtained during N2, particularly during the last sleep period. This pattern of sleep-related cardiovascular changes is different from that typically observed in good sleepers, which may suggest increased sympathetic activation during the earlier part of the night among individuals with chronic insomnia. Additional studies are needed to examine blood pressure and heart rate changes during sleep in order to document further the long-term cardiovascular risks associated with chronic insomnia. Canadian Institutes of Health Research (MOP42504) and Fonds de recherche du Québec - Santé (32207).
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".