0291 ASSOCIATION BETWEEN STRESS-INDUCED AROUSAL AND NOCTURNAL SLEEP
Bibliographic record
Abstract
Stress and hyperarousal contribute to insomnia. Elevated sleep reactivity, characterized by increased sensitivity in physiological stress response and sleep system, might also constitute a vulnerability to hyperarousal and future insomnia. The present study examined acute stress-induced arousal and its impact on sleep. Participants (26.7 ± 5.3 years; 66.7% female) were adults with insomnia (INS; n=10) and good sleepers (n=20). Based on the Ford Insomnia Response to Stress Test (FIRST=20), good sleepers were further sub-divided into high vulnerability (HV; n=10) and low vulnerability (LV; n=10) to insomnia groups. Participants underwent two nights of polysomnography. On the stress condition night, the Trier Social Stress Test (TSST) was administered. Physiological arousal variables included salivary cortisol, heart rate (HR), heart rate variability (HF, LF/HF ratio), and blood pressure. Subjective arousal was assessed with the Pre-Sleep Arousal Scale. Cortisol, HR, and systolic blood pressure were significantly elevated in response to the TSST in all groups (all ps<.05). The INS group had greater total cortisol secretion (p<.05) and increased cortisol reactivity (p<.05) compared to the LV group across the test period. The INS group also reported greater pre-sleep cognitive arousal (p<.01) and had elevated cortisol secretion at bedtime (p<.05) than the LV group. No significant differences on these measures were observed between the HV and INS groups. Further, cortisol stress response (r=.41, p=.030) and elevated LF/HF ratio (r=.39, p=.039) were each significantly associated with longer nocturnal awakenings. Increased blood pressure was associated with longer sleep onset latency (ravg=.43, p< .05) and reduced sleep efficiency (ravg=- .41, p< .05). Overall, participants with insomnia showed greater acute cortisol response and (subjective and physiological) bedtime hyperarousal than the LV group but not compared to the HV group. Elevated stress-induced arousal is associated with increased sleep disruptions. These findings support the hyperarousal conceptualization of insomnia and suggest that increased stress reactivity and hyperarousal might represent a trait-like vulnerability in certain good sleepers. More research is warranted to validate and expand our preliminary findings. Research supported by the Canadian Institutes of Health Research (MOP42504 and B0512201) and the Fonds de recherche de Québec - Santé (32207).
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".