A particle filter motion prediction algorithm based on an autoregressive model for real-time MRI-guided radiotherapy of lung cancer
Bibliographic record
Abstract
Abstract This work introduces a 2D motion prediction algorithm for lung tumors applied to dynamic MR images that combines intrafractional tumor deformations. It is developed in the context of MR-linac treatments and evaluates uniform and patient-specific margins about the gross tumor volume to optimize the tumor coverage. Seven early stage non-small cell lung cancer patients were imaged in treatment position with a 1.5 T magnetic resonance using a balanced steady-state free precession sequence for one minute at a rate of four images per second and were instructed to breathe normally. The particle filter, in combination with the autoregressive model, is used to sequentially track and predict the tumor position 250 ms in the future from the current image. In addition, the autocontour extracted from a previous study (Bourque et al 2016 Med. Phys. 43 5161–9) is projected to the predicted position and various margins are evaluated. Averaged over all patients, the root mean square errors are (1.3 ± 0.5) mm and (2.0 ± 0.8) mm with and without prediction, respectively, and the difference in centroid position is (1.1 ± 0.4) mm with the prediction. The addition of the prediction algorithm leads to inferior errors for all cases. With such predictor, enlarging the propagated contour by a uniform 2 mm margin leads to a minimum recall of 97% over the entire patient population. Considering patient-specific margins based on 2 σ of the Gaussian distribution around the mean error, the margins vary from 0.8 to 3.0 mm in anterior–posterior direction and from 1.2 to 3.2 mm in the superior–inferior direction. This study concludes that the advantage of such prediction algorithm highly depends on the tumor motion characteristics. For both uniform and patient-specific margins evaluation, smaller treatment margins could be used when combined to an accurate tracking and motion prediction algorithm. These results could offer guidance for future MR-guided lung tumor treatments.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".