Cortical Abnormalities Associated With Pediatric and Adult Obsessive-Compulsive Disorder: Findings From the ENIGMA Obsessive-Compulsive Disorder Working Group

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.

Full frame distilled prediction

Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

Candidate categories

Meta-epidemiology (narrow), Science and technology studies, Research integrity

Consensus categories

Meta-epidemiology (narrow), Science and technology studies

Domain

Candidate signal: noneConsensus signal: none

Study design

Candidate signal: ObservationalConsensus signal: none

Genre

Candidate signal: ReviewConsensus signal: Review

Teacher disagreement score

0.522

Threshold uncertainty score

1.000

Validation status

machine_predicted_unvalidated · codex-gemma-dda1882f352a

Codex and Gemma teacher scores by category

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Teacher spread

0.289 · how far apart the two teachers sit on this one work

Validation status

score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

OBJECTIVE: Brain imaging studies of structural abnormalities in OCD have yielded inconsistent results, partly because of limited statistical power, clinical heterogeneity, and methodological differences. The authors conducted meta- and mega-analyses comprising the largest study of cortical morphometry in OCD ever undertaken. METHOD: -weighted MRI scans of 1,905 OCD patients and 1,760 healthy controls from 27 sites worldwide were processed locally using FreeSurfer to assess cortical thickness and surface area. Effect sizes for differences between patients and controls, and associations with clinical characteristics, were calculated using linear regression models controlling for age, sex, site, and intracranial volume. RESULTS: In adult OCD patients versus controls, we found a significantly lower surface area for the transverse temporal cortex and a thinner inferior parietal cortex. Medicated adult OCD patients also showed thinner cortices throughout the brain. In pediatric OCD patients compared with controls, we found significantly thinner inferior and superior parietal cortices, but none of the regions analyzed showed significant differences in surface area. However, medicated pediatric OCD patients had lower surface area in frontal regions. Cohen's d effect sizes varied from -0.10 to -0.33. CONCLUSIONS: The parietal cortex was consistently implicated in both adults and children with OCD. More widespread cortical thickness abnormalities were found in medicated adult OCD patients, and more pronounced surface area deficits (mainly in frontal regions) were found in medicated pediatric OCD patients. These cortical measures represent distinct morphological features and may be differentially affected during different stages of development and illness, and possibly moderated by disease profile and medication.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

The record

Venue

American Journal of Psychiatry

Topic

Obsessive-Compulsive Spectrum Disorders

Field

Psychology

Canadian institutions

not available

Funders

CilagNational Institute of Mental HealthCanadian Institutes of Health ResearchPfizer PharmaceuticalsCumming School of Medicine, University of CalgaryMathison Centre for Mental Health Research and EducationCampbell Family Mental Health Research InstitutePfizerKunming Medical UniversityUniversity of California, Los AngelesHamilton Health Sciences FoundationMuseo Storico della Fisica e Centro Studi e Ricerche Enrico FermiMedical Research CouncilServierUniversitat Autònoma de BarcelonaNOMIS StiftungUniversity of Cape TownTourette Association of AmericaHumboldt-Universität zu BerlinH. Lundbeck A/SHospital for Sick ChildrenSeoul National University HospitalNational Institute of Biomedical Imaging and BioengineeringAmsterdam NeuroscienceEli Lilly and CompanyKoninklijke Nederlandse Akademie van WetenschappenCentro de Investigación Biomédica en Red de Salud MentalYale UniversityKarolinska InstitutetDeutsche ForschungsgemeinschaftNederlandse Organisatie voor Wetenschappelijk OnderzoekSunovionUniversität ZürichBundesministerium für Bildung und ForschungCollege of Medicine, Seoul National UniversityUniversiteit van AmsterdamUniversitat de BarcelonaVrije Universiteit AmsterdamUniversity of OxfordSeoul National UniversityOlga Mayenfisch StiftungUniversidade Federal do ABCSouth African Medical Research CouncilSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungNational Institute of Mental Health and NeurosciencesHamilton Health SciencesPalo Alto Health SciencesUniversity of TorontoCanadian Network for Mood and Anxiety TreatmentsUniversity of Southern CaliforniaWellcome TrustNational Science FoundationUniversity of CambridgeAllerganUniversidade de São PauloAstraZenecaBristol-Myers Squibb

Keywords

Obsessive compulsiveCortex (anatomy)Frontal cortexBrain sizeMedicineNeuroimagingPosterior parietal cortexMagnetic resonance imagingNeurosciencePsychologyPsychiatryRadiology

Has abstract in OpenAlex

yes

API

/api/v1/works/W2608867270