Tempol, Vitamin C and Vitamin E Improve Endothelial Dysfunction, Regress Vascular Hypertrophy and Prevent Progression of Hypertension and Renal Dysfunction in Stroke-Prone Shr
Bibliographic record
Abstract
P35 Antioxidant vitamins reduce oxidative stress in vascular injury associated with atherosclerosis and balloon injury. The role of these agents in the pathogenesis of hypertension is unclear. We investigated effects of vitamins C and E and the superoxide dismutase (SOD) mimetic, tempol, on development of blood pressure, vascular structure and endothelial function in salt-loaded stroke-prone SHR (SHRSP). 16 week-old SHRSP (n=26) on a high salt diet (4% NaCl) were randomly divided into 4 groups: control (C), Vit C (1000 mg/d), Vit E (1000 IU/d) and tempol (1 mmol/d). Systolic blood pressure (SBP) and renal function were assessed weekly. 6 weeks after treatment rats were killed. Vascular structure (media:lumen ratio) and endothelial function (acetylcholine (Ach)-induced vasodilation) were assessed in small mesenteric arteries mounted as pressurized preparations. SBP increased from 204± to 265±6 mmHg in C group. Progression of hypertension was prevented in Vit C (234±4 mmHg), Vit E (227±11mmHg) and tempol (208±8 mmHg) groups. Development and severity of proteinuria was delayed in all treated groups compared with C. The media:lumen ratio was reduced (p
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".