1159 SLEEP-RELATED RESPIRATORY ABNORMALITIES DURING SEIZURES
Bibliographic record
Abstract
Epilepsy patients have more than twentyfold greater risk of death when compared to the general population and it often occur at night or in relation to sleep. Prior studies have found that specific cardiorespiratory abnormalities occurred more preferentially during sleep as compared to wakefulness in adult epilepsy patients. Whether nocturnal seizures are more likely to be associated with higher oxygen desaturation drop is uncertain. Therefore, we examined the temporal pattern of oxygen saturation before, during, and after seizures occurring either during sleep or wakefulness. Respiratory measures were retrospectively examined in 40 recorded seizures from 20 adult patients with epilepsy (11 female; 22–53 years old) admitted for long-term video-EEG monitoring at the Brigham and Women’s Hospital. Oxygen saturation levels were analyzed at 4 time-points: 1) Preictally (10-s before seizure onset), 2) ictally (during a seizure), 3) immediately postictally (10-s after a seizure), and 4) 5-min postictally (5 minutes after a seizure). Seventeen (43%) seizures occurred during sleep and 23 (58%) during wakefulness. Seizure duration did not differ between sleep and wake states. Seizures from sleep were associated with lower nadir oxygen saturation as compared to seizures from wakefulness, both during a seizure and immediately after a seizure (ps < 0.05). Seizures from sleep were also associated with a significantly larger desaturation drop as compared to seizures from wakefulness across all time-points (-7.6 ± 4.6 and -2.9 ± 1.8, respectively; p < 0.05). Despite comparable oxygen saturation levels at baseline (preictally), our results show that seizures occurring during sleep are associated with larger oxygen desaturation drop as compared to wakefulness. Moreover, during nocturnal seizures, oxygen saturation levels remain significantly lower, even few seconds after seizure termination. These findings suggest that nocturnal seizures are more likely to be associated with more severe and longer hypoxemia events, which might have some implication for sudden death in epilepsy patients. Harvard Catalyst Grant, Canadian Institutes of Health Research (CIHR)
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".