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37th International Symposium on Intensive Care and Emergency Medicine (part 1 of 3)
V. Karavana, Iain M Smith, G. Kanellis, Ioanna Sigala, Thomas Kinsella, S. Zakynthinos, J. Chen, X. Zhang, Anping Liu, Fan Guo, S. Liu, Yi Yang, Haibo Qiu, D. G. Grimaldi, Emın Kaya, Özlem Acicbe, I. Kayaalp, Sinan Aşar, Murat Doğan, Gülay Eren, Oya Hergünsel, D. Pavelescu, Ioana Marina Grințescu, L. Mirea, Mariateresa Guanziroli, Miriam Gotti, Massimo Cressoni, Luciano Gattinoni, Chiara Chiurazzi, Susanne Spano, G. Vergani, Antonella Marino, Fabrizia Massaro, Aristidis Moustakas, Stefan Johansson, Anders Larsson, Gaetano Perchiazzi, F. M. Guo, Juntong Chen, Mingming Xue, Lei Yang, Misa Fister, Rihard Knafelj, M. A. Suzer, Mustafa Emre Kavlak, Hakan Korkut Atalan, Bülent Güçyetmez, Nahit Çakar, David Weller, A. F. Grootendorst, A. Dijkstra, T. Martijn Kuijper, Berry I. Cleffken, Adrian Regli, Bart De Keulenaer, Peter Vernon van Heerden, Daniel Hadfield, Philip Hopkins, Bethany Penhaligon, Fiona Reid, Nicholas Hart, Gerrard F. Rafferty, Giacomo Grasselli, Barbara Cambiaghi, Nilde Eronia, Alfio Bronco, Chiara Abbruzzese, Nicola De Rossi, Giuseppe Foti, Gianluigi Li Bassi, Otávio T. Ranzani, Theodor Kolobow, Lorenzo Berra, Vieri Parrini, Hassan Kandil, Giovanni Salati, S. Livigni, Alessandro Amatu, Massimo Girardis, G. Moise, Antonella Vezzani, Simone Lindau, Ana Sánchez Torres, Alberto M. Torres‐Cantero, Michele Umbrello, Martina Taverna, Paolo Formenti, Giovanni Mistraletti, Francesco Vetrone, Alessandro Baisi, Davide Chiumello, A. G. Garnero, Dominik Novotni, Jean-Michel Arnal, Martin Urner, Eddy Fan, Martin Dres, Stefannie Vorona, L. Brochard, Niall D. Ferguson, Ewan C. Goligher, C Leung, Gavin M. Joynt, Wai‐Tat Wong, A. Lee, C.D. Gomersall, S. Poels, Michaël P. Casaer, Miet Schetz, Greet Van den Berghe, Geert Meyfroidt, Bernhard Holzgraefe, Laura B. von Kobyletzki, Francesca Becherucci, Stefano Batacchi, M. Cozzolino, Federico Franchi, Simona Di Valvasone, M Ferraro, H. Phiphitthanaban, Petch Wacharasint, Virissorn Wongsrichanalai, Amornchai Lertamornpong, Onuma Pengpinij, Anan Wattanathum, Nittha Oer-Areemitr, Maria Boddi, Giovanni Cianchi, E. Cappellini, Marco Ciapetti, Manuela Bonizzoli, A Peris, Andrea Lazzeri, Manuela Bonizzoli, M. L. Katsin, M. Y. Hurava, A. M. Dzyadzko, Alexander Hermann, Peter Schellongowski, Anja Bojic, Katharina Riss, Oliver Robak, Wolfgang Lamm, Wolfgang R. Sperr, Thomas Staudinger, Laura Tadini Buoninsegni, M. Bonizzoli, Jean Parodo, A Ottaviano, L. Cecci, Elisabetta Corsi, Valdo Ricca, Aritz Pérez Ruiz de Garibay, B. Ende-Schneider, C. Schreiber, Bernhard Kreymann, Franco Turani, Marco Resta, Dario Niro, Peter J. Castaldi, Gabriele Boscolo, G. Gonsales, Silvia Martini, Antonio Belli, Lucia Zamidei, M Falco, T. E. Lamas, João João Mendes, Alessandro Galazzi, B. Benco, Filippo Binda, Laura Masciopinto, Alfredo Lissoni, Ileana Adamini, Antonio Pesenti, Thanyalak Thamjamrassri, Jittiya Watcharotayangul, Pawin Numthavaj, S. Kongsareepong, Jacinto Gómez Higuera, D. Cabestrero, L. Rey, G. Narváez, Aarón Blandino, S. Saéz, A. Mohamed, Michael C. Sklar, Laveena Munshi, Tommaso Mauri, Laura Alban, Cecilia Turrini, Paolo Taccone, Eleonora Carlesso, C. Marenghi, Savino Spadaro, Carlo Alberto Volta, D. Cabestrero Alonso, L. Rey González, Andrea Franci, G. Stocchi, G. Cappuccini, Filippo Socci, Cristiana Guetti, P. Rastrelli, Andrzej Nestorowicz, Jarosław Glapiński, J. Wosko, Frédéric Duprez, T. Bonus, Grégory Cuvelier, S. Mashayekhi, S. Ollieuz, Grégory Reychler, Iurii Kuchyn, K. Bielka, A. Sergienko, Huw Jones, Cathy Day, S. C. Park, Seok Ran Yeom, Sheila Nainan Myatra, Sudeep Gupta, V. Rajnala, JV Divatia, J. Villalobos Silva, O. Aguilera Olvera, Raphael Schulte, Mary Bermúdez, L. Pariente Zorrilla, H. Lopez Ferretis, K. Trejo García, Neringa Balčiūnienė, Jurgita Ramšaitė, Oresta Kriukelytė, Asta Krikščionaitienė, Tomas Tamošuitis, Pierpaolo Terragni, Luca Brazzi, De Falco, Laura Pistidda, Gloria Magni, Lorenzo Bartoletti, Luciana Mascia, Chiara Filippini, V. Marco Ranieri, Anna Kyriakoudi, Νikoletta Ρovina, Ourania Koltsida, Elissavet Konstantellou, Matina Kardara, Eirini Kostakou, GG Gavriilidis, Ioannis Vasileiadis, Νikolaos Koulouris, Antonia Koutsoukou, Wouter van Snippenburg, Anke Kröner, Marleen Flim, Marc P. Buise, Raphael J. B. Hemler, Peter E. Spronk, B. Noffsinger, Bhajan Singh, Lisen E. Hockings, C. Spina, Federica Magni, Cristina Di Giambattista, Alessia Vargiolu, Giuseppe Citerio, Gaetano Scaramuzzo, Andreas D. Waldmann, Stephan H. Böhm, Riccardo Ragazzi, Serge J Heines, Ulrich Strauch, Marcel C.G. van de Poll, Paul M.H.J. Roekaerts, D. C. J. J. Bergmans, Simone Sosio, Veronica Punzi, Angiolino Asta, Janusz Mroczka, Andrey I. Yaroshetskiy, Н А Резепов, Igor Mandel, Б Р Гельфанд, E. Ozen, Emre Karakoç, Ayşe AYYILDIZ, Sadık Kara, Süheyla Ekemen, Birgül Yelken, Wael Saasouh, J. Freeman, Alparslan Turan, Walid Sellami, M. Bousselmi, Walid Samoud, Hédi Gharsallah, Iheb Labbène, Mustapha Ferjani, Luigi Vetrugno, Federico Barbariol, Francesco Forfori, I. Regeni, Carlo Della Rocca, Diane Jansen, Annemijn H. Jonkman, Jonne Doorduin, Lisanne H. Roesthuis, J van der Hoeven, Leo Heunks, Stefano Arrigoni Marocco, Maurizio Bottiroli, Riccardo Pinciroli, Valeria Galanti, Angelo Calini, M.P. Gagliardone, G. Bellani, Roberto Fumagalli, Davide Ippolito, V. Sala, Valeria Meroni, Giacomo Bellani, Mohammed F. Elbanna, Aly Mohamed Abdelmohsen, M. Yahia, Silvia Mongodi, Francesco Mojoli, Gabriele Via, G. Tavazzi, Francesca Fava, Marco Pozzi, B. Bouhemad, Francisco Ruiz-Ferrón, JM Serrano Simón, Marina Gordillo-Resina, Violeta Chica-Sáez, M. Ruiz Garcia, Rosa Vela-Colmenero, M. Redondo-Orts, Carolina M Gontijo-Coutinho, Tatiana Mirabetti Ozahata, P. Nocera, Daniel Franci, Thiago Martins Santos, Oliviero Fochi, Stefano Gatti, Mirco Nacoti, Davide Signori, Daniele Bonacina, Ezio Bonanomi, Emilio Bonvecchio, Andréa Stella, Emanuela Roldi, Anita Orlando, Marta Luperto, Danila Trunfio, Gabriella Licitra, Riccardo Martinelli, D. Vannini, G Giuliano, Erik Näslund, Lars‐Göran Lindberg, I. Lund, Robert Frithiof, Amy Nichols, Sri Ram Pentakota, Bhavani Shankar Kodali, Andrius Pranskūnas, Inga Kiudulaitė, Jūratė Šimkienė, Diana Damanskytė, Živilė Pranskūnienė, Justina Arstikyte, Dinas Vaitkaitis, Vidas Pilvinis, Marius Brazaitis, Rachel Pool, Håkon Haugaa, Alexandra Botero, D Escobar, Donald Maberry, Tor Inge Tønnessen, Brian S. Zuckerbraun, Hernando Gómez, Hernando Lyons, Alex Trimmings, Roberta Domizi, Claudia Scorcella, Elisa Damiani, Silvia Pierantozzi, Stefania Tondi, V Monaldi, Alexie A. Carletti, Samuele Zuccari, Erica Adrario, P. Pelaia, Abele Donati, Sigita Kazūne, Andris Grabovskis, K. Volceka, Uldis Rubīns, Martine E. Bol, Martje M. Suverein, Thijs Delnoij, Ronald H. Driessen, Tammo Delhaas, Martin Pöll, Jan-Willem E. M. Sels, Mathieu Jozwiak, Matthieu Chambaz, Pierre Sentenac, Christian Richard, Zouheir Bitar, O. Maadarani, Rashed Al Hamdan, Manu L. N. G. Malbrain, M.H. Chew, Jihad Mallat, Takashi Tagami, S. Hundeshagen, Stefan Wolf, Wolfgang Huber, Sebastian Mair, J Aron, Michael Adlam, Gunjeet Dua, Liuquan Mu, L. Chen, Joo Heung Yoon, Gilles Clermont, Artur Dubrawski, Zainab Al Duhailib, K. Al Assas, Azam Shafquat, Nawal Salahuddin, John Donaghy, P. Morgan, Liana Văleanu, Mihaela Stefan, Sophie Provenchère, Dan Longrois, Andrew Shaw, Monty Mythen, Douglas C. Shook, David K. Hayashida, Sibyl H. Munson, Ashley Sawyer, Maryanne Mariyaselvam, M Blunt, PJ Young, Narongwit Nakwan, Bodin Khwannimit, P. Checharoen, Per Werner Möller, Stefan Bloechlinger, Amy J. Bloch, Stephan M. Jakob, Jukka Takala, J. M. Van den Brule, Roeland F. Stolk, Elisabeth J. Vinke, Lex M. van Loon, P. Pickkers, J.G van der Hoeven, Matthijs Kox, Cornelia Hoedemaekers, Pietro Bertini, Denise Colosimo, S. Gonnella, Giulia Brizzi, G. Mancino, Rubia Baldassarri, Michael R. Pinsky, Daniele Amitrano, Tomaž Goslar, Dušan Štajer, P. Radsel, Rien de Vos, N. Bussink-van Dijk, G. Stringari, G. Cogo, Alessandro Devigili, M. Ceola Graziadei, E Bresadola, P. Lubli, S. Amella, F. Marani, Enrico Polati, Leonardo Gottin, Laura Colinas, Giselle Riquelme Hernández, R. Vicho, M. Serna, Alfonso Canabal Berlanga, Rafael Cuena, Jean–Louis Teboul, François Dépret, Khouloud Sassi, Alexander Herner, N. Abded, M. Elghonemi, Abdelilah Monir, J. Nikhilesh, T. Apurv, Andrea Über, Anne V. Grossestreuer, Ari Moskowitz, Priya Patel, Mathias J. Holmberg, Michael W. Donnino, Colin A. Graham, Kevin Kei Ching Hung, Ronson Sze Long Lo, Ling Yan Leung, K. H. Lee, Chun Yu Yeung, S. Chan, Н. В. Трембач, И. Б. Заболотских, Juliana Caldas, Ronney B. Panerai, Juliano Pinheiro de Almeida, Gisele Queiroz de Oliveira, Jaquelline Maria Jardim, Edson Bor‐Seng‐Shu, Maria Eduarda Freitas de Lima, Ricardo de Carvalho Nogueira, Suely Pereira Zeferino, Thompson Robinson, Ludhmila Abrahão Hajjar, G. Ferreira, Manuela Lima Barros de Oliveira, R. Norgueira, R. Groehs, Larissa Ferreira‐Santos, Filomena Regina Barbosa Gomes Galas, Geice Kelly Sousa de Oliveira, Fábio Biscegli Jatene, José R. Ribeiro, Fábio Antônio Gaiotto, Leila Sheila Silva Lisbôa, Stéphanie Itala Rizk, Rendrik F. Franco, Renan Bernardi Kalil, Małgorzata Chlabicz, Bożena Sobkowicz, Karol Kamiński, Remigiusz Kazimierczyk, Włodzimierz J. Musiał, Agnieszka Tycińska, Mladen Širanović, A. Gopcevic, Željka Gavranović, A. H. Horvat, Helena Krolo, Bojan Rode, L. Videc, Ahlem Trifi, Sami Abdellatif, Khaoula Ben Ismail, Abir Bouattour, Frank Daly, Rochdi Nasri, Salah Ben Lakhal, Alexandra Beurton, V. Girotto, Laurą Galarza, T. Guedj, Pablo Mercado, M. Karaman Iliæ, Vavulina Nn, Lucija Stojčić, Jean-Emmanuel Alphonsine, Christopher Lai, N. Tapanwong, P. Chuntupama, Josef Hoellthaler, Tobias Lahmer, Roland M. Schmid, Heath Latham, Charles D. Bengtson, Lewis Satterwhite, Mindy Stites, Stephen Simpson, Tomasz Składzień, Michał Cicio, Jarosław Garlicki, Wojciech Serednicki, Jerzy Wordliczek, Álvaro Ortiz de Salazar, M. Espinoza, Napplika Kongpolprom, Natthawan Sanguanwong, S. Jonnada, Caroline Gerrard, Nicola Jones, Thomas F. Morley, P Thorburn, Т. С. Мусаева, Sanne Ter Horst, Miklós Lipcsey, Rafael Kawati, Andreas Pikwer, Johan Rasmusson, Markus Castegren, Alexandra Shilova, A. A. Yafarova, М. Yu. Gilyarov, D. Stojiljkovic, Alexandru Ulici, Shannon Reidt, Trần Khánh Lâm, J. Jancik, D Ragab, Khaled Taema, W.M. Farouk, M. Saad, X. Liu, Sophia Montissol, Lars W. Andersen, Fotis Perlikos, Maria Lagiou, Αpostolos Papalois, Christos Κroupis, Ioannis K. Toumpoulis, D. Carter, Salvatore Sardo, Giovanni Landoni, Suneerat Kongsayreepong, R. Sungsiri, P. Wongsripunetit, Patricia Marchio, Sol Guerra‐Ojeda, M. Gimeno-Raga, María Dolores Mauricio, S. Vallés, Constanza Aldasoro, A. Jordá, M. Aldasoro, José M. Vila, U. B. Borg, Anna-Maria Neitenbach, Manuel Ignacio Monge García, Pedro Guijo González, Manuel Gracia Romero, Paula Saludes Orduña, Aitana Cano, Andrew Rhodes, RM Grounds, Maurizio Cecconi, Christopher M. Lee, Joseph Rinehart, Jennifer De Los Santos, Cecilia Canales, M. Cannesson, Feras Hatib, Thomas Scheeren, Vasiliki Chantziara, A. Vassi, G. Michaloudis, Elias Sanidas, Spyretta Golemati, R. M. Bateman, A. Mokhtar, Waleed Abdulazeez Omar, K. Abdel Aziz, H. El Azizy, Daniel Nielsen, Jon Gitz Holler, Annmarie Touborg Lassen, Mats Eriksson, Gunnar Strandberg, A Larsson, C. Capoletto, Rosana Ely Nakamura, S. Risk, E. Osawa, C. Park, F. Dias, N. D’Arrigo, Fabrício Piccoli Fortuna, S. Redaelli, L. Zerman, L. Becker, Tomás M. Rodríguez Serrano, L. Cotes, Francieli Caroline de Ramos, Luciane Maria Fadel, F. Coelho, Ciro Leite Mendes, J. S. Réal, Bruno Gregnanin Pedron, M.L. Franco Kuroki, Eduardo Leite Vieira Costa, Luciano César Pontes Azevedo
Bibliographic record
VenueCritical Care · 2017
Typearticle
Languageen
FieldMedicine
TopicHemodynamic Monitoring and Therapy
Canadian institutionsWestern UniversitySinai Health SystemUniversity of Toronto
Fundersnot available
KeywordsMedicineIntensive care medicineIntensive careMedical emergencyEmergency medicine
Abstract
Introduction: Aberrant inflammation is a hallmark of acute respiratory distress syndrome (ARDS) pathophysiology.JAK/ STAT3 pathway is critical for macrophages and neutrophils activation and persistent inflammation.This study aims to investigate the therapeutic potential of inhibiting JAK1/3 activity using the small-molecule R548 inhibitor in LPS induce lung injury model.Methods: Lung injury was induced in adult male C57BL/6 mice, by intratracheal LPS administration followed by post subcutaneous injection of R548 inhibitor R548 inhibitor, prodrug for the active compound, R507 (Rigel Pharmaceuticals Inc.).Mice sacrificed at 6 h and 24 h after LPS administration.Lung inflammation was examined by protein content, number and type of inflammatory cells in bronchoalveolar lavage fluid (BALF).Protein expression levels of JAK1, p-STAT3, ERK1/2 were analysed by Western blotting.Results: LPS administration increased BALF cellularity, total protein content, and neutrophils cells number at both 6 h and 24 h.Elevated levels of JAK1, p-STAT3 and ERK1/2 protein expression were observed.In addition, post LPS treatment with the JAK 1/3 inhibitor significantly reduces BALF protein content (P < 0.05), total cells number (P < 0.01), neutrophils cells number (P < 0.01) as early as 6 h.Moreover, R548 treatment decreased JAK1 protein expression by 2 fold (P < 0.01) and p-STAT3 levels by 2.7 fold (P < 0.001) below the LPS group.Conclusions: These data suggest the JAK/STAT3 signaling pathway plays a critical role in ARDS mediated lung inflammation and injury.Additional studies are warranted to further investigate JAK/STAT3 inhibition as a therapeutic treatment for this serious and life threatening disease. P2Stable genetic alterations of CXCR7 regulate the CXCL12/CXCR7 axis, a new "passport" ± for the homing of mscs
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Other · Consensus signal: none
Teacher disagreement score0.098
Threshold uncertainty score0.328
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.002 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.001 | 0.002 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.098 | 0.049 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.044
GPT teacher head0.388
Teacher spread0.344 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreOther
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
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Citations33
Published2017
Admission routes1
Has abstractyes